Results 161 to 170 of about 767,801 (242)

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

Advanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño, Víctor M. de la Oliva Roque, Javier‐Ignacio Ramirez‐Lopez, David P. Kreil, Joaquín Dopazo, Carlos Loucera   +5 more
wiley   +1 more source

Comorbidity and modifiable risk factors in multiple sclerosis. [PDF]

Ther Adv Neurol Disord
Zhang Y, Dobson R, Giovannoni G.
europepmc   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Fuzzy logic for preanesthetic risk assessment in cataract surgery patients. [PDF]

Medicine (Baltimore)
Yilmaz G, Küçüksaraç G, Esen O, Akdaş N, Balkan B, Sandal B, Salihoğlu E, Sayin DT, Kara Y, Koçak İ, Şahin AS, Salihoğlu Z.   +11 more
europepmc   +1 more source

Sphingomonas paucimobilis‐Driven Epithelial–Endothelial Transition in Adenomyosis Pathogenesis

Advanced Science, EarlyView.
This study identifies epithelial–endothelial transition (EET) as a novel adenomyosis pathogenic mechanism driven by Sphingomonas paucimobilis colonization. Systematic inhibitor experiments validate a TNFα→NF‐κB→MMP signaling cascade essential for EET. Critically, bacterial culture supernatant fails to induce pathological changes, demonstrating viable ...
Peigen Chen, Hao Shi, Junxian He, Ziyu Liu, Yuanyuan Zhu, Xiaoyan Liang, Guihua Liu, Xing Yang   +7 more
wiley   +1 more source

Emphysematous cystitis in a non-diabetic elderly woman with severe cardiac comorbidities: A case report. [PDF]

Radiol Case Rep
Brathen E, D'Hulst P.
europepmc   +1 more source

Cytoprotection Concepts for Ischemic Stroke in the Recanalization Era

Advanced Science, EarlyView.
This review provides detailed information on modern cytoprotective strategies for ischemic stroke in the context of recanalization therapies. It derives their rationale based on contemporary knowledge of stroke pathophysiology and discusses the role of advanced imaging approaches as well as concepts for novel clinical trial designs.
Johannes Boltze, Marc Fisher
wiley   +1 more source

Comparison between older adults and youth with body constitution: A cross-sectional study. [PDF]

Medicine (Baltimore)
Chu CT, Huang PY, Hu WL, Hung YC.
europepmc   +1 more source

Periodontitis Induces B Cell‐Macrophage Crosstalk to Exacerbate Glucose Dysregulation in Obesity

Advanced Science, EarlyView.
In obesity, periodontitis exacerbates hyperglycemia and exhibits a liver‐centric preference for glucose regulation. This occurs through a periodontitis‐driven circuit between pathogenic B cells and hepatic macrophages. Their reciprocal expansion, orchestrated by the NLRP3/IL‐18 signaling pathway, amplifies metabolic inflammation and disrupts glucose ...
Wen‐Zhen Lin, Lu‐Jun Zhou, Hui‐Lin Ye, Ting Liu, Bo‐Yan Chen, Xue‐Bing Bai, Jun Zhang, Lan Bai, Lin‐Juan Du, Yuan Liu, Yong‐Li Wang, Hong Zhu, Yu‐Lin Li, Shuo Xu, Xiao‐Qian Meng, Guo‐Cai Tian, Yan Liu, Wu‐Chang Zhang, Ya‐Qin Zhu, Sheng‐Zhong Duan   +19 more
wiley   +1 more source

Profile of SARS-CoV-2/HIV-1 coinfection in patients from the extreme south of Brazil. [PDF]

Braz J Microbiol
Lemos LC, de Almeida Perret Magalhães B, Da Mota LD, Basso RP, Gonçalves CV, De Santana ACA, Lobato RC, De Martínez AMB, Von Groll A, Xavier MO, Ramis IB, Soares MA, Da Hora VP.   +12 more
europepmc   +1 more source