Results 11 to 20 of about 767,801 (242)

Perivascular macrophages in high-fat diet-induced hypothalamic inflammation

Journal of Neuroinflammation, 2022
Brain macrophages and microglia are centrally involved in immune surveillance of the central nervous system. Upon inflammatory stimuli, they become reactive and release key molecules to prevent further damage to the neuronal network.
Natalia F. Mendes, Licio A. Velloso
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A20 deubiquitinase controls PGC-1α expression in the adipose tissue

Lipids in Health and Disease, 2018
Background Peroxisome proliferator-activated receptor γ coactivator- 1alpha (PGC-1α) plays an important role in whole body metabolism and, particularly in glucose homeostasis.
Bruna Bombassaro, Leticia M. Ignacio-Souza, Carla E. Nunez, Daniela S. Razolli, Rafael M. Pedro, Andressa Coope, Eliana P. Araujo, Elinton A. Chaim, Licio A. Velloso   +8 more
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Comorbidities of migraine [PDF]

Frontiers in Neurology, 2010
Migraine is a common neurological disorder and can be severely disabling during attacks. The highest prevalence occurs between the ages of 25 and 55 years, potentially the most productive period of life. Migraine leads to a burden not only for the individual, but also for the family and society in general.
Wang, Shuu-Jiun, Chen, Ping-Kun, Fuh, Jong-Ling   +2 more
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The Bile Acid TUDCA Improves Beta-Cell Mass and Reduces Insulin Degradation in Mice With Early-Stage of Type-1 Diabetes

Frontiers in Physiology, 2019
Type 1 diabetes (T1D) is characterized by impairment in beta-cell mass and insulin levels, resulting in hyperglycemia and diabetic complications. Since diagnosis, appropriate control of glycaemia in T1D requires insulin administration, which can result ...
Gabriela Alves Bronczek, Gabriela Alves Bronczek, Jean Franciesco Vettorazzi, Gabriela Moreira Soares, Mirian Ayumi Kurauti, Cristiane Santos, Maressa Fernandes Bonfim, Everardo Magalhães Carneiro, Sandra Lucinei Balbo, Antonio Carlos Boschero, José Maria Costa Júnior   +10 more
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Burden and associated phenotypic characteristics of tuberculosis infection in adult Africans with diabetes: a systematic review

Scientific Reports, 2023
Diabetes mellitus (DM) increases the risk of developing tuberculosis infection (TBI). However, the evidence on the burden and phenotypic characteristics of TBI in African patients with DM is limited.
Davis Kibirige, Irene Andia-Biraro, Andrew Peter Kyazze, Ronald Olum, Felix Bongomin, Rose Mwanje Nakavuma, Phillip Ssekamatte, Reagan Emoru, Goretti Nalubega, Nyasatu Chamba, Kajiru Kilonzo, Sweetness Naftal Laizer, Lucy Elauteri Mrema, Willyhelmina Olomi, Lilian Tina Minja, Nyanda Elias Ntinginya, Issa Sabi, Philip C. Hill, Lindsey te Brake, Reinout van Crevel, Katrina Sharples, Julia Critchley   +21 more
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Plasma Angiotensin II Is Increased in Critical Coronavirus Disease 2019

Frontiers in Cardiovascular Medicine, 2022
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) employs angiotensin-converting enzyme 2 (ACE2) as its receptor for cell entrance, and studies have suggested that upon viral binding, ACE2 catalytic activity could be inhibited; therefore ...
Rafael L. Camargo, Bruna Bombassaro, Milena Monfort-Pires, Eli Mansour, Andre C. Palma, Luciana C. Ribeiro, Raisa G. Ulaf, Ana Flavia Bernardes, Thyago A. Nunes, Marcus V. Agrela, Rachel P. Dertkigil, Sergio S. Dertkigil, Eliana P. Araujo, Eliana P. Araujo, Wilson Nadruz, Wilson Nadruz, Maria Luiza Moretti, Licio A. Velloso, Licio A. Velloso, Andrei C. Sposito, Andrei C. Sposito   +20 more
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Ventricular Fibrosis and Coronary Remodeling Following Short-Term Exposure of Healthy and Malnourished Mice to Bisphenol A

Frontiers in Physiology, 2021
Bisphenol-A (BPA) is an endocrine disruptor associated with higher risk of insulin resistance, type 2 diabetes, and cardiovascular diseases especially in susceptible populations.
Marta García-Arévalo, Marta García-Arévalo, Estela Lorza-Gil, Estela Lorza-Gil, Leandro Cardoso, Thiago Martins Batista, Thiago Martins Batista, Thiago Reis Araujo, Thiago Reis Araujo, Luiz Alberto Ferreira Ramos, Miguel Arcanjo Areas, Angel Nadal, Everardo Magalhães Carneiro, Everardo Magalhães Carneiro, Ana Paula Davel   +14 more
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Short-Term High-Fat Diet Consumption Reduces Hypothalamic Expression of the Nicotinic Acetylcholine Receptor α7 Subunit (α7nAChR) and Affects the Anti-inflammatory Response in a Mouse Model of Sepsis

Frontiers in Immunology, 2019
Sepsis is one of the leading causes of death in hospitalized patients and the chronic and low-grade inflammation observed in obesity seems to worsen susceptibility and morbidity of infections.
Anelise Cristina Parras Souza, Anelise Cristina Parras Souza, Camilla Mendes Souza, Camilla Mendes Souza, Camila Libardi Amaral, Camila Libardi Amaral, Simone Ferreira Lemes, Simone Ferreira Lemes, Leticia Foglia Santucci, Leticia Foglia Santucci, Marciane Milanski, Marciane Milanski, Adriana Souza Torsoni, Adriana Souza Torsoni, Marcio Alberto Torsoni, Marcio Alberto Torsoni   +15 more
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ARHGAP21 Acts as an Inhibitor of the Glucose-Stimulated Insulin Secretion Process

Frontiers in Endocrinology, 2020
ARHGAP21 is a RhoGAP protein implicated in the modulation of insulin secretion and energy metabolism. ARHGAP21 transient-inhibition increase glucose-stimulated insulin secretion (GSIS) in neonatal islets; however, ARHGAP21 heterozygote mice have a ...
Sandra M. Ferreira, José M. Costa-Júnior, Mirian A. Kurauti, Nayara C. Leite, Fernanda Ortis, Luiz F. Rezende, Helena C. Barbosa, Antonio C. Boschero, Gustavo J. Santos   +8 more
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Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation

Journal of Neuroinflammation, 2017
Background The consumption of large amounts of dietary fats is one of the most important environmental factors contributing to the development of obesity and metabolic disorders.
Nathalia R. V. Dragano, Carina Solon, Albina F. Ramalho, Rodrigo F. de Moura, Daniela S. Razolli, Elisabeth Christiansen, Carlos Azevedo, Trond Ulven, Licio A. Velloso   +8 more
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