Results 21 to 30 of about 767,801 (242)

Mineralocorticoid Receptor Antagonism Prevents the Synergistic Effect of Metabolic Challenge and Chronic Kidney Disease on Renal Fibrosis and Inflammation in Mice

Frontiers in Physiology, 2022
Obesity and/or metabolic diseases are frequently associated with chronic kidney disease and several factors associated with obesity may contribute to proteinuria and extracellular matrix production.
Roberto Palacios-Ramirez, Ixchel Lima-Posada, Benjamin Bonnard, Marie Genty, Amaya Fernandez-Celis, Judith Hartleib-Geschwindner, Fabienne Foufelle, Natalia Lopez-Andres, Krister Bamberg, Frederic Jaisser, Frederic Jaisser   +10 more
doaj   +1 more source

The partial inhibition of hypothalamic IRX3 exacerbates obesityResearch in context

EBioMedicine, 2019
Background: The Iroquois homeobox 3 (Irx3) gene has been identified as a functional long-range target of obesity-associated variants within the fat mass and obesity-associated protein (FTO) gene. It is highly expressed in the hypothalamus, and both whole-
Thiago Matos de Araujo, Daniela S. Razolli, Felipe Correa-da-Silva, Jose C. de Lima-Junior, Rodrigo S. Gaspar, Davi Sidarta-Oliveira, Sheila C. Victorio, Jose Donato, Jr, Young-Bum Kim, Licio A. Velloso   +9 more
doaj   +1 more source

Tecido adiposo: suas cores e versatilidade

HU Revista, 2020
Introdução: O tecido adiposo e suas células tem sido amplamente estudados devido à sua relação íntima com a obesidade. Objetivo: Identificar aspectos históricos e relevantes sobre o avanço na compreensão da função metabólica do tecido adiposo, sobretudo ...
Helena Fonseca Raposo
doaj   +1 more source

Psoriasis comorbidities

Journal of Dermatological Treatment, 2008
Psoriasis is a chronic and debilitating inflammatory disease associated with serious comorbidities. Psoriasis can have a significant impact on a patient's quality of life and is associated with loss of productivity, depression, and an increased prevalence of malignancy.
Alice B, Gottlieb, Chun, Chao, Frank, Dann   +2 more
openaire   +2 more sources

Beet (Beta vulgaris L.) stalk and leaf supplementation changes the glucose homeostasis and inflammatory markers in the liver of mice exposed to a high-fat diet

Food Chemistry: Molecular Sciences, 2021
Although beet stalks and leaves are not consumed and are usually discarded, they are an important source of bioactive flavonoids possessing antioxidant and anti-inflammatory activity. The aim of this study was to assess the effect of supplementation with
Isabela Micheletti Lorizola, Josiane Érica Miyamoto, Ana Luiza Figueiredo Vieira, Beatriz Rocchetti Sumere, Rosângela Maria Neves Bezerra, Marcio Alberto Torsoni, Adriana Souza Torsoni, Mauricio Ariel Rostagno, Marciane Milanski, Caroline Dário Capitani   +9 more
doaj   +1 more source

Comorbidity [PDF]

, 2020
This book introduces a new theory on the substantial comorbidity that exists between many illnesses and disorders and concurrent symptoms such as pain, impaired sleep and fatigue. The specific illnesses and disorders discussed include obesity, diabetes mellitus type-II, medical illnesses including cardiovascular disease and sleep-disordered breathing ...
Brown, Rhonda, Thorsteinsson, Einar
openaire   +3 more sources

Metabolic sexual dimorphism in hypothalamic Fezf1 neuron-specific BDNF knockout

Biology of Sex Differences
Background Brain-derived neurotrophic factor (BDNF) is highly expressed in the hypothalamus where it exerts regulatory functions over neurogenesis, reproduction, energy balance, and metabolism.
Dayana Cabral-da-Silva, Ariane M. Zanesco, Fernando Valdivieso-Rivera, Ana L. Gallo-Ferraz, Marcela R. Simões, Bruna Bombassaro, Carlos H. Sponton, Licio A. Velloso   +7 more
doaj   +1 more source

Whole-Body ARHGAP21-Deficiency Improves Energetic Homeostasis in Lean and Obese Mice

Frontiers in Endocrinology, 2019
Inhibition of Rab-GAP TBC1 domain family member 1 (TBC1D1) reduces body weight and increases energy expenditure in mice. Here, we assessed the possible involvement of GTPase activating protein 21 (ARHGAP21), a Rho-GAP protein, in energy homeostasis. Wild-
Gabriela Moreira Soares, Gabriela Moreira Soares, Lucas Zangerolamo, Lucas Zangerolamo, Jose Maria Costa-Júnior, Jose Maria Costa-Júnior, Jean Franciesco Vettorazzi, Jean Franciesco Vettorazzi, Everardo Magalhães Carneiro, Everardo Magalhães Carneiro, Sara Teresinha Saad, Antonio Carlos Boschero, Antonio Carlos Boschero, Helena Cristina Barbosa-Sampaio, Helena Cristina Barbosa-Sampaio   +14 more
doaj   +1 more source

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Brown fat triglyceride content is associated with cardiovascular risk markers in adults from a tropical region

Frontiers in Endocrinology, 2022
Brown adipose tissue (BAT) is regarded as an interesting potential target for the treatment of obesity, diabetes, and cardiovascular diseases, and the detailed characterization of its structural and functional phenotype could enable an advance in these ...
Milena Monfort-Pires, Giulianna Regeni-Silva, Prince Dadson, Guilherme A. Nogueira, Mueez U-Din, Mueez U-Din, Sandra R. G. Ferreira, Marcelo Tatit Sapienza, Kirsi A. Virtanen, Kirsi A. Virtanen, Kirsi A. Virtanen, Licio A. Velloso   +11 more
doaj   +1 more source