Results 51 to 60 of about 767,801 (242)

Abnormal brown adipose tissue mitochondrial structure and function in IL10 deficiency

EBioMedicine, 2019
Background: Inflammation is the most relevant mechanism linking obesity with insulin-resistance and metabolic disease. It impacts the structure and function of tissues and organs involved in metabolism, such as the liver, pancreatic islets and the ...
José C. de-Lima-Júnior, Gabriela F. Souza, Alexandre Moura-Assis, Rodrigo S. Gaspar, Joana M. Gaspar, Andréa L. Rocha, Danilo L. Ferrucci, Tanes I. Lima, Sheila C. Victório, Ivan L.P. Bonfante, Claudia R. Cavaglieri, José C. Pareja, Sérgio Q. Brunetto, Celso D. Ramos, Bruno Geloneze, Marcelo A. Mori, Leonardo R. Silveira, Gesmar R.S. Segundo, Eduardo R. Ropelle, Lício A. Velloso   +19 more
doaj   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Hypothalamic Microglial Activation in Obesity: A Mini-Review

Frontiers in Neuroscience, 2018
Emerging data demonstrate that microglia activation plays a pivotal role in the development of hypothalamic inflammation in obesity. Early after the introduction of a high-fat diet, hypothalamic microglia undergo morphological, and functional changes in ...
Natália F. Mendes, Natália F. Mendes, Natália F. Mendes, Young-Bum Kim, Lício A. Velloso, Lício A. Velloso, Eliana P. Araújo, Eliana P. Araújo   +7 more
doaj   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

CXCR3-expressing myeloid cells recruited to the hypothalamus protect against diet-induced body mass gain and metabolic dysfunction

eLife
Microgliosis plays a critical role in diet-induced hypothalamic inflammation. A few hours after a high-fat diet (HFD), hypothalamic microglia shift to an inflammatory phenotype, and prolonged fat consumption leads to the recruitment of bone marrow ...
Natalia Mendes, Ariane Zanesco, Cristhiane Aguiar, Gabriela F Rodrigues-Luiz, Dayana Silva, Jonathan Campos, Niels Olsen Saraiva Camara, Pedro Moraes-Vieira, Eliana Araujo, Licio A Velloso   +9 more
doaj   +1 more source

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu, Marcus C. Ng, Gavin P. Winston, Sabrina Schaly, Garima Shukla, Lysa Boissé Lomax   +5 more
wiley   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

The global diet quality score as an indicator of adequate nutrient intake and dietary quality – a nation-wide representative study

Nutrition Journal
Background The Global Diet Quality Score (GDQS) was developed to be a simple, timely and cost-effective tool to track, simultaneously, nutritional deficiency and non-communicable disease risks from diet in diverse settings.
Marina M. Norde, Sabri Bromage, Dirce M. L. Marchioni, Ana Carolina Vasques, Megan Deitchler, Joanne Arsenaut, Aline M. de Carvalho, Lício Velloso, Walter Willett, Edward Giovannucci, Bruno Geloneze   +10 more
doaj   +1 more source

Effectiveness of immunosuppressive therapy in children with autoimmune hepatitis and autoimmune sclerosing cholangitis

Medičnì Perspektivi
Autoimmune liver diseases in children, particularly autoimmune hepatitis and autoimmune sclerosing cholangitis, represent a challenging clinical issue due to their variable clinical course, diagnostic complexity, and suboptimal therapeutic efficacy ...
M.B. Dyba, V.S. Berezenko, O.M. Tkalyk, Kh.Z. Dmytrenko   +3 more
doaj   +1 more source