Results 71 to 80 of about 1,569,893 (337)

The triple challenges associated with age-related comorbidities in Down syndrome [PDF]

, 2014
Background Major increases in the survival of people with Down syndrome during the last two generations have resulted in extended periods of adulthood requiring specialist care, which in turn necessitates greater understanding of the nature, timing and ...
Bittles, A.H., Dye, D.E., Glasson, E.J.
core   +1 more source

A dynamic network approach for the study of human phenotypes [PDF]

, 2009
The use of networks to integrate different genetic, proteomic, and metabolic datasets has been proposed as a viable path toward elucidating the origins of specific diseases.
A Barrat, A Hinks, A Rzhetsky, AB Begovich, AJ Lusis, Albert-László Barabási, C Benesch, CA Hidalgo, CA Hidalgo, César A. Hidalgo, D Lauderdale, DS Lee, GS Cooper, H Goehler, I Feldman, J Hatten, J Kobberling, J Lim, J Zhang, JB Mitchell, JF Rual, K-I Goh, Lauren Ancel Meyers, LI Iezzoni, MA Pujana, MC Oldham, N Craddock, Nicholas A. Christakis, Nicholas Blumm, P McGuffin, P Wordsworth, S Schneeweiss, SE Ahnert, SE Calvano, SF Grant, U Stelzl   +35 more
core   +5 more sources

Psychosocial Outcomes in Patients With Endocrine Tumor Syndromes: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The combination of disease manifestations, the familial burden, and varying penetrance of endocrine tumor syndromes (ETSs) is unique. This review aimed to portray and summarize available data on psychosocial outcomes in patients with ETSs and explore gaps and opportunities for future research and care.
Daniël Zwerus, Floortje Strobbe, Annemarie A. Verrijn Stuart, Hanneke M. van Santen, Gerlof D. Valk, Sasja A. Schepers, Rachel S. van Leeuwaarde   +6 more
wiley   +1 more source

A Consensus on the Diagnosis and Treatment of Acromegaly Comorbidities: An Update.

Journal of Clinical Endocrinology and Metabolism, 2020
OBJECTIVE The aim of the Acromegaly Consensus Group was to revise and update the consensus on diagnosis and treatment of acromegaly comorbidities last published in 2013.
A. Giustina, A. Barkan, A. Beckers, N. Biermasz, Beverly M K Biller, C. Boguszewski, M. Bolanowski, V. Bonert, M. Bronstein, F. Casanueva, D. Clemmons, A. Colao, D. Ferone, M. Fleseriu, S. Frara, Mônica R. Gadelha, E. Ghigo, M. Gurnell, A. Heaney, Ken K. Y. Ho, A. Ioachimescu, L. Katznelson, F. Keleştimur, J. Kopchick, M. Kršek, S. Lamberts, M. Losa, A. Luger, P. Maffei, M. Marazuela, G. Mazziotti, M. Mercado, P. Mortini, S. Neggers, Alberto M. Pereira, S. Petersenn, M. Puig-Domingo, R. Salvatori, I. Shimon, C. Strasburger, S. Tsagarakis, A. J. van der Lely, J. Wass, M. Zatelli, S. Melmed   +44 more
semanticscholar   +1 more source

Brown fat triglyceride content is associated with cardiovascular risk markers in adults from a tropical region

Frontiers in Endocrinology, 2022
Brown adipose tissue (BAT) is regarded as an interesting potential target for the treatment of obesity, diabetes, and cardiovascular diseases, and the detailed characterization of its structural and functional phenotype could enable an advance in these ...
Milena Monfort-Pires, Giulianna Regeni-Silva, Prince Dadson, Guilherme A. Nogueira, Mueez U-Din, Mueez U-Din, Sandra R. G. Ferreira, Marcelo Tatit Sapienza, Kirsi A. Virtanen, Kirsi A. Virtanen, Kirsi A. Virtanen, Licio A. Velloso   +11 more
doaj   +1 more source

El reto del envejecimiento y la complejidad farmacoterapéutica en el paciente VIH+ [PDF]

, 2018
Objective: To describe the current knowledge and management of aging and pharmacotherapeutic complexity in HIV + patients. Method: A review of literature was carried out, including articles, originals or reviews, published in English or Spanish, from ...
Abdel Kader Martín, Laila, Morillo Verdugo, Ramón A., Ramos Blanco, José Ramón, Álvarez de Sotomayor Paz, María   +3 more
core   +3 more sources

Changes in Body Composition in Children and Young People Undergoing Treatment for Acute Lymphoblastic Leukemia: A Systematic Review and Meta‐Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment.
Lina A. Zahed, Raquel Revuelta Iniesta, Mary Fewtrell, Julie Lanigan, Breeana Gardiner, Graeme O'Connor   +5 more
wiley   +1 more source

Systematic Literature Review of Psychiatric Comorbidities in Adults with Epilepsy

Journal of Clinical Neurology, 2021
Background and Purpose Mental illness is disproportionately common in people with epilepsy (PWE). This systematic literature review identified original research articles that reported the prevalence of psychiatric comorbidities based upon clinical ...
Elaine Lu, N. Pyatka, C. Burant, M. Sajatovic   +3 more
semanticscholar   +1 more source

Bidirectional shifts in Pm20d1 expression impact thermogenesis and metabolism

Molecular Medicine
Background Peptidase M20 domain containing 1 (PM20D1) is a secreted N-fatty acyl amino synthase and hydrolase that controls tissue and blood levels of N-fatty acyl amino acids. In brown adipocytes, N-fatty acyl amino acids bind to mitochondria and act as
Marcela R. Simoes, Ana L. Gallo-Ferraz, Bruna Bombassaro, Fernando Valdivieso-Rivera, Guilherme A. S. Nogueira, Milena Monfort-Pires, Marcos Vinicius da Cruz, Ariane M. Zanesco, Nayra Fernanda-Oliveira, Leonardo Reis Silveira, Roger F. Castilho, Carlos H. Sponton, Licio A. Velloso   +12 more
doaj   +1 more source

External validation of a risk stratification model to assist shared decision making for patients starting renal replacement therapy [PDF]

, 2016
BACKGROUND: Shared decision making is nowadays acknowledged as an essential step when deciding on starting renal replacement therapy. Valid risk stratification of prognosis is, besides discussing quality of life, crucial in this regard.
De Meester, Johan, De Moor, Bart, Lemahieu, Wim, Peeters, Patrick, Van Biesen, Wim, Veys, Nic   +5 more
core   +3 more sources