Mary Nguyen-Nielsen,1 Mette Nørgaard,1 Jacob Bonde Jacobsen,1 Michael Borre,2 Reimar Wernich Thomsen,1 Mette Søgaard1 1Department of Clinical Epidemiology, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark ...
Søgaard M +5 more
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Metabolic and Fluid Biomarkers Support Microglia Activation in Amyotrophic Lateral Sclerosis
ABSTRACT Amyotrophic lateral sclerosis is an incurable neurodegenerative disease involving motor neuron degeneration and metabolic and immune dysfunction. We combined clinical data, cerebrospinal fluid biomarkers and fluorodeoxyglucose positron emission tomography with magnetic resonance imaging to investigate the role of reactive microglia in disease ...
Matteo Zanovello +10 more
wiley +1 more source
Diffuse MRI Edema Predicts Relapse in Cerebral Amyloid Angiopathy–Related Inflammation
ABSTRACT Objective To identify MRI predictors of relapse and quantify relapse and mortality risk in cerebral amyloid angiopathy–related inflammation (CAA‐RI). A secondary objective was to assess the association between mycophenolate mofetil use and relapse risk. Methods We performed a retrospective cohort study of 36 patients with CAA‐RI treated at the
G. Abbas Kharal +10 more
wiley +1 more source
Association Between Neurofilament Light Chain and Real‐World Ambulatory Function in Progressive MS
ABSTRACT Objective Neurofilament light chain (NfL) is a biomarker of neuroaxonal injury in multiple sclerosis (MS), yet associations with functional outcomes remain unclear. Longitudinal associations between serum NfL (sNfL) and daily step count (STEPS) from wearable devices were assessed in a large international progressive MS cohort.
Gabby B. Joseph +5 more
wiley +1 more source
Performance of Different Comorbidity Indices in Predicting Mortality in Danish Pancreatic Cancer Patients [PDF]
Jakob Kirkegård,1– 3 Emil Riahi,1,2 Rasmus Ilkjær,1,2 Frank Viborg Mortensen,1,2 Uffe Heide-Jørgensen2,4 1Department of Surgery, HPB Section, Aarhus University Hospital, Aarhus, Denmark; 2Department of Clinical Medicine, Aarhus University, Aarhus ...
Riahi E +4 more
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Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy
ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini +9 more
wiley +1 more source
Eva Bjerre Ostenfeld,1,2 Mette Nørgaard,1 Reimar Wernich Thomsen,1 Lene Hjerrild Iversen,3 Jacob Bonde Jacobsen,1 Mette Søgaard1 1Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; 2Department of Surgery A ...
Søgaard M +5 more
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Predictors of change in treatment outcome for parent-delivered guided CBT bibliotherapy for children with anxiety: Effects of age, severity and comorbidity at long term follow-up [PDF]
This thesis is concerned with an exploration of low-intensity treatments for common mental health problems in childhood and adolescence. Part one is a narrative literature review of trials of low-intensity interventions for children and adolescents with ...
Brown, A
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ABSTRACT Objective Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP‐A) is an inflammatory central nervous system disorder with variable outcomes. Relapse occurs in a subset of patients, but early predictors remain unclear. We aimed to identify admission‐available features associated with 1‐year recurrence and develop an interpretable ...
Qingting Hong +10 more
wiley +1 more source
Abstracts of the 11th International Conference on Developmental Coordination Disorder (DCD11)
DCD11 – Developmental coordination disorder and other neurodevelopmental disorders: a focus on comorbidity; Toulouse, France, July 2-4, 2015Comorbidity refers to the presence of two or more disorders in the same person (especially DCD, dyslexia and ...
Congress Abstracts, DCD11
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