Results 171 to 180 of about 699,670 (339)
Advanced Science, EarlyView.In vivo experiments suggest that cardiomyocyte hypertrophy is an early manifestation of cardiac pathological changes induced by chronic psychological stress. In vivo and in vitro experiments suggest that the corticosterone‐glucocorticoid receptor‐LAMA5 axis mediates cardiomyocyte hypertrophy induced by chronic psychological stress. The clinical results
Chuanjing Zhang +10 more
wiley +1 more source
Use of comorbidity scores for control of confounding in studies using administrative databases [PDF]
, 2000 Sebastian Schneeweiß, Malcolm Maclure
openalex +1 more source
Dynein‐Dependent Endo‐Lysosomal Degradation Drives Lewy Body Disorders Accompanied by Aβ Pathology
Advanced Science, EarlyView.This study investigates the impact of Aβ plaques on α‐synuclein (αSyn) pathologies in dementia with Lewy bodies (DLB). Co‐culturing primary neurons with AD mouse brain slices reveals impaired dynein‐dependent organelle trafficking, affecting αSyn degradation. Activating Rab7 restores this process, reducing αSyn inclusions.
Linlin Zhou +14 more
wiley +1 more source
Microphysiological Uremia Model Reveals Biophysical Potentiators of Vascular Dysfunction
Advanced Science, EarlyView.A microfluidic platform of engineered blood vessels is developed to study the role of mechanical forces in immune cell adhesion and extravasation in uremic microenvironments. Elevated pressure increases monocyte activity, with ICAM‐1 as a key driver. Matrix density influences monocyte phenotypes, but the uremic environment consistently promoted a pro ...
Mitesh Rathod +9 more
wiley +1 more source
Case Study: Missed Diagnosis and Mistreatment of Unrecognized Comorbid Graves Disease
, 1999 Joseph Woolston, Annmarie Caracansi
openalex +1 more source
Aging and the Spectral Properties of Brain Hemodynamics
Advanced Science, EarlyView.As the brain ages, its metabolic demands decline—but not uniformly. Here, spectral slope flattening of resting‐state fMRI signals is proposed as a potential biomarker of pathologic brain aging. A subset of older adults diverges from youthful spectral and metabolic patterns, with changes linked to frontal white matter pathology and regional loss of ...
Ki Yun Park +9 more
wiley +1 more source
Comorbid Generalized Anxiety Disorder, Phobia, and Panic Disorder [PDF]
, 2000 Nikki Brannon, Dean Schuyler
openalex +1 more source
Advanced Science, EarlyView.The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang +9 more
wiley +1 more source