A retrospective study of the impact of comorbidity, polypharmacy and demographic factors on patient inclusion and healthcare delivery in phase I oncology trials. [PDF]
Nemat H+7 more
europepmc +1 more source
Osteoblast‐CD4+ CTL Crosstalk Mediated by SIRT1/DAAM2 Axis Prevents Age‐Related Bone Loss
In the osteoblastic niche, SIRT1 activates and recruits CD4+ CTLs by increasing DAAM2 expression via EZH2 deacetylation and boosting the secretion of key chemokines, such as CCL3, CCL5, and CXCL10. Then, CD4+ CTL directly eliminates senescent osteoblasts in an MHC‐II‐dependent way, thereby slowing down the process of bone ageing and effectively ...
Bin Yang+20 more
wiley +1 more source
The evolution of comorbidities in chronic diseases among Chinese middle-aged and elderly people: Evidence from the CHARLS (2015-2020). [PDF]
Zhang Z+6 more
europepmc +1 more source
Adult Attention Deficit (ADD) with and without comorbid problems
Duncan G. Campbell
openalex +1 more source
Migraine comorbidity: from genotype to phenotype [PDF]
Giuseppe Nappi+6 more
openalex +1 more source
Circardian rhythm disorder (CRD) causes abnormal expression of intestinal Period 2 (Per2) gene, which compromising intestinal barrier integrity and altering the gut microenvironment. Microbiota dysbiosis and aberrant metabolites production drive central inflammation, impair neurogenesis, and promote functional deficits, ultimately facilitating the ...
Huiliang Zhang+16 more
wiley +1 more source
The comorbidities of diarrhea and acute respiratory tract infection and risk factors among under-five children in 45 low- and middle-income countries. [PDF]
Tekeba B+7 more
europepmc +1 more source
The comorbidity of bulimia nervosa, substance abuse and depression.
Kim Schnare-Hayes
openalex +2 more sources
Psychiatric Comorbidity in Chronic Epilepsy: Identification, Consequences, and Treatment of Major Depression [PDF]
Bruce P. Hermann+2 more
openalex +1 more source