Results 191 to 200 of about 1,034,220 (415)

Comorbid anxiety predicts lower odds of depression improvement during smartphone-delivered psychotherapy [PDF]

arXiv
Comorbid anxiety disorders are common among patients with major depressive disorder (MDD), and numerous studies have identified an association between comorbid anxiety and resistance to pharmacological depression treatment. However, the impact of anxiety on the effectiveness of non-pharmacological interventions for MDD is not as well understood.
arxiv  

Key Connectomes and Synaptic‐Compartment‐Specific Risk Genes Drive Pathological α‐Synuclein Spreading

Advanced Science, EarlyView.
Utilizing a stereotaxic injection mouse model and a novel mathematical approach, this study uncovers key subnetworks that drive pathological α‐synuclein (α‐Syn) progression in Parkinson's disease (PD). Remarkably, just 2% of the strongest connections in the connectome are sufficient to predict its spread.
Yuanxi Li, Justin Torok, Shujing Zhang, Jessica Ding, Ning Wang, Courtney Lau, Shruti Kulkarni, Chaitali Anand, Julie Tran, Michael Cheng, Claire Lo, Binbin Lu, Yanzi Sun, Robert Damoiseaux, Xia Yang, Ashish Raj, Chao Peng   +16 more
wiley   +1 more source

Graph Transformer with Disease Subgraph Positional Encoding for Improved Comorbidity Prediction [PDF]

arXiv
Comorbidity, the co-occurrence of multiple medical conditions in a single patient, profoundly impacts disease management and outcomes. Understanding these complex interconnections is crucial, especially in contexts where comorbidities exacerbate outcomes. Leveraging insights from the human interactome (HI) and advancements in graph-based methodologies,
arxiv  

KDM6A Deficiency Induces Myeloid Bias and Promotes CMML‐Like Disease Through JAK/STAT3 Activation by Repressing SOCS3

Advanced Science, EarlyView.
Lysine demethylase 6A (KDM6A), an epigenetic regulator expressed in hematopoietic stem and progenitor cells (HSPCs), plays a critical role in hematopoietic homeostasis. Deficiency of KDM6A induces myeloid lineage skewing and drives the development of a chronic myelomonocytic leukemia (CMML)‐like disease.
Huiqiao Chen, Shufen Wang, Ruoyu Dong, Pinghui Yu, Tianyu Li, Liangning Hu, Mowang Wang, Zijun Qian, Hongyu Zhou, Xiaoyan Yue, Limengmeng Wang, Haowen Xiao   +11 more
wiley   +1 more source

Psychiatric Comorbidity and Length of Stay in the General Hospital

, 1994
Stephen M. Saravay, Michael R. Lavin
openalex   +1 more source

Comparison of Large Language Model with Aphasia

Advanced Science, EarlyView.
Large language models (LLMs) answer almost all questions fluently but often inaccurately, which resembles a specific type of aphasia in humans. Using a data‐driven analysis called energy landscape analysis, this study reveals similarities in the internal information dynamics between LLMs and the brains of humans with receptive aphasia, such as Wernicke'
Takamitsu Watanabe, Katsuma Inoue, Yasuo Kuniyoshi, Kohei Nakajima, Kazuyuki Aihara   +4 more
wiley   +1 more source

GLS1‐Mediated Redundancy in Glutamate Accelerates Arterial Calcification via Activating NMDAR/Ca2+/β‐Catenin Pathway

Advanced Science, EarlyView.
GLS1 is a novel contributor to arterial calcification. GLS1‐catalyzed glutamate exerts the promoting effects on osteogenic reprogramming in arteries. NMDAR, a glutamate receptor, is also activated and overexpressed during arterial calcification.
Ziting Zhou, Bing Dong, Dayu He, Jianshuai Ma, Yun Kong, Huijin Zhu, Chen Xie, Tiecheng Yang, Xin Zhen, Zhengzhipeng Zhang, Zhaohui He, Jinkun Cheng, Aoran Huang, Jie Chen, Ruo Wu, Huiyong Yin, Yanlian Chen, Jun Tao, Hui Huang   +18 more
wiley   +1 more source

“Comorbid” Insomnia

Indian Journal of Psychological Medicine, 2011
M S Reddy, Arindam Chakrabarty
openaire   +4 more sources

Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration

Advanced Science, EarlyView.
The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan, Meiqian Wu, Chaonan Zhu, Hao Yu, Minh Duc Pham, Katharina Bottermann, Yijie Mao, Yue Wang, Mathias Langner, Mirko Peitzsch, Arka Provo Das, Silke Kauferstein, Jonathan Ward, Peter Mirtschink, Andreas Michael Zeiher, Stefanie Dimmeler, Jaya Krishnan   +16 more
wiley   +1 more source

Corrigendum: Berberine Improves Benign Prostatic Hyperplasia via Suppression of 5 Alpha Reductase and Extracellular Signal-Regulated Kinase in Vivo and in Vitro

Frontiers in Pharmacology, 2019
Dong-Hyun Youn, Dong-Hyun Youn, Jinbong Park, Jinbong Park, Hye-Lin Kim, Yunu Jung, Yunu Jung, JongWook Kang, JongWook Kang, Seona Lim, Seona Lim, Gahee Song, Gahee Song, Hyun Jeong Kwak, Jae-Young Um, Jae-Young Um   +15 more
doaj   +1 more source