Advanced Therapeutics, EarlyView.This review explores how antibody engineering and display technologies are driving therapeutic advances against mosquito‐borne orthoflaviviruses such as Zika, dengue, and yellow fever viruses. It highlights diverse neutralizing targets on the envelope protein, including the conserved fusion loop, and discusses how Fc engineering, rational antigen ...
Ana Clara Barbosa Antonelli +5 more
wiley +1 more source
Comorbidities, safety and persistence in phase III clinical trials in multiple sclerosis. [PDF]
J Neurol Neurosurg PsychiatrySalter A +4 more
europepmc +1 more source
Assessment and Treatment of Psychosocial Comorbidities in Patients With Neuropathic Pain [PDF]
, 2010 Dennis C. Turk +4 more
openalex +1 more source
ATF5‐Dependent GDF15 Expression Mediates Anesthesia‐Induced Neuroprotection Against Stroke
Advanced Science, EarlyView.Anesthesia‐induced preconditioning protects against perioperative stroke. By manipulating ATF5 in excitatory neurons, it is shown that anesthesia‐driven ATF5 upregulation activates the mitochondrial unfolded protein response (UPRmt) and elevates GDF15 expression.
Xianshu Ju +11 more
wiley +1 more source
Tic severity and executive functioning in children and adolescents: a moderated mediation model of premonitory urges and comorbidity. [PDF]
Child Adolesc Psychiatry Ment HealthLu Y +5 more
europepmc +1 more source
Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis
Advanced Science, EarlyView.Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang +16 more
wiley +1 more source
The Association Between Socioeconomic Position and Infection Risk After Hip Fracture Surgery: A Nationwide Cohort Study of 54,853 Patients. [PDF]
Clin EpidemiolGadgaard NR +5 more
europepmc +1 more source
Advanced Science, EarlyView.This work demonstrates that endothelial EphA4 limits Tie2 activation and curbs leptomeningeal collateral expansion after ischemic stroke. Pharmacological activation of Tie2 by an Ang‐1 mimetic or genetic loss of EphA4 stimulates collateral vessel growth, improves cerebral perfusion, and enhances neurological recovery.
Alexandra M. Kaloss +9 more
wiley +1 more source
Key genes and associated mechanisms of PCOS and EC comorbidity: A bioinformatics analysis. [PDF]
Medicine (Baltimore)Yao Y, Zhu S, Zhu X.
europepmc +1 more source
Advanced Science, EarlyView.In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi +10 more
wiley +1 more source