Results 251 to 260 of about 765,292 (350)

Temporal and Cell‐Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1

Advanced Science, EarlyView.
Chd1, the Drosophila homologue of mammalian CHD2 ‐ a gene linked to autism, epilepsy, and intellectual disability, is required for synaptic homeostatic plasticity. Chd1 in glia is necessary for the rapid induction of synaptic homeostasis, whereas Chd1 in motoneurons, muscle, and glia is critical for long‐term maintenance.
Danielle T. Morency, Tao Cui, Yimei Cai, Chloe Lok, Rachel E. Nokku, Ruoxian Huang, Grace L. Chu, Yumeng Xie, Saleem W. Abu‐Tayeh, Kaikai He, Chengjie Qiu, Junyi Wang, Paxton M. Paganelli, Ting Wang, Gabrielle Williams, Sreejith Nair, Huadong Pei, Dion K. Dickman, Stefano Vicini, Tingting Wang   +19 more
wiley   +1 more source

A comprehensive nationwide registry study of noncommunicable disease comorbidities and death in cancer patients in Norway-the NCDNOR project. [PDF]

Sci Rep
Lergenmuller S, Robsahm TE, Nilssen Y, Dalene KE, Nystad W, Meyer HE, Stigum H, Hjellvik V, Kjerpeseth LJ, Ariansen I, Larsen IK.   +10 more
europepmc   +1 more source

Mo1276 Abuse Histories Predict Greater Functional GI and Pain Comorbidities in Irritable Bowel Syndrome (IBS) Patients

, 2015
Navya D. Kanuri, Pratibha Abraham, Steven E. Bruce, Kamila S. White, Benjamin Cassell, Britt M. Gott, Billy D. Nix, C. Prakash Gyawali, Gregory S. Sayuk   +8 more
openalex   +1 more source

RETREG1‐Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis

Advanced Science, EarlyView.
Reticulophagy regulator 1 (RETREG1) maintains dendritic cell (DC) maturation and function in early sepsis. Mechanistically, activating transcription factor 6 (ATF6) acts as a direct transcription factor regulating RETREG1 expression in response to sepsis‐induced endoplasmic reticulum (ER) stress.
Ren‐Qi Yao, Chao Ren, Li‐Yu Zheng, Jing‐Yan Li, Wen‐Feng Wu, Yu‐Xuan Li, Li‐Xue Wang, Yu Duan, Lu Wang, Shuang‐Qing Liu, Peng‐Yi He, Peng‐Yue Zhao, Sen Tong, Zhi‐Xuan Li, Tuo Zhang, Meng‐Yao Wu, Shu‐Ting Wei, Ning Dong, Yao Wu, Hui Zhang, Xiao‐Mei Zhu, Zi‐Cheng Zhang, Guo‐Sheng Wu, Zhao‐Fan Xia, Xiao‐Hui Du, Hong‐Jun Kang, Zui Zou, Dao‐Lin Tang, Yong‐Ming Yao   +28 more
wiley   +1 more source

Hospital variation in the treatment of cT1a renal cancer. [PDF]

BJUI Compass
Bresser CC, van der Nat PB, Yildirim H, Kersten BJP, Leenarts HJJ, Aben KKH, Zondervan PJ, Dijksman LM, Polm PD, Garvelink MM, van Melick HHE, Santeon RCC Working Group.   +11 more
europepmc   +1 more source

Comorbid psychiatric illness and its association with glycemic control among adults with diabetes mellitus: a hospital based cross sectional study in Nepal

, 2016
SB Pant, SP Ojha, M Chapagain, P Tulachan, Sahadeb Prasad Dhungana   +4 more
openalex   +2 more sources

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

Advanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño, Víctor M. de la Oliva Roque, Javier‐Ignacio Ramirez‐Lopez, David P. Kreil, Joaquín Dopazo, Carlos Loucera   +5 more
wiley   +1 more source

Identifying Undiagnosed High-Risk Suicidality Cases by Matching Patients With a Similar Comorbidity Burden: Retrospective Observational Study. [PDF]

JMIR Form Res
Bode L, Xu R, Garber M, Mandl KD, Mcmurry AJ.   +4 more
europepmc   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Cross-sectional and longitudinal cognitive trajectories associated with dementia comorbidity clusters: Results from a 10-year follow-up real-world outpatient memory clinic in Brazil. [PDF]

Alzheimers Dement
Lazzaretti FJ, Botton LP, Lokschin CG, de Oliveira Felício A, Patatt J, da Costa JC, Aguzzoli CS, Schilling LP.   +7 more
europepmc   +1 more source