Results 251 to 260 of about 476,841 (315)

Functional autonomy, comorbidities and cognitive decline: a mediation analysis in neurocognitive disorders. [PDF]

Front Aging Neurosci
Valente G, Bauco C, Bucca C, Corte F, Petrillo A, Tonietti D, Di Sturco N, Diotaiuti P.   +7 more
europepmc   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Influence of Diabetes Mellitus on the Development of Multidrug-Resistant Tuberculosis (MDR-TB) in Relation With Genetic Mutations of <i>M. tuberculosis</i> Isolates in Ethiopia. [PDF]

Can J Infect Dis Med Microbiol
Seid A, Nureddin S.
europepmc   +1 more source

An Implantable Optogenetics‐Engineered Hydrogel for Amelioration of Rheumatoid Arthritis through Light‐Controlled Metabolic Reprogramming of Synovial Macrophages

Advanced Science, EarlyView.
An implantable hydrogel is designed to enable in situ and on‐demand secretion of GLP‐1 in synovium through blue light irradiation to activate GLP‐1R/HK2/VDAC1 pathway for upregulating tricarboxylic acid cycle and oxidative phosphorylation in macrophage, facilitating tissue repair and bone erosion recovery.
Dahai Hu, Yaru Sun, Qi Lu, Yi Zhang, Jieruo Li, Huige Hou, Huajun Wang, Hui Tang, Yunsong Zhang, Xiaofei Zheng, Qingsong Mei   +10 more
wiley   +1 more source

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

Comorbidity in Patients with Idiopathic Pulmonary Fibrosis: Evaluation Using the Charlson, TORVAN and GAP Indices. [PDF]

J Clin Med
Torres Tienza S, de Miguel-Díez J, Ortega CG, Jareño Esteban JJ.   +3 more
europepmc   +1 more source

Network analysis of sleep disorders, anxiety, and loneliness among the community-dwelling older adults. [PDF]

Front Public Health
Li X, Mao L.
europepmc   +1 more source

Longitudinal trends and sociodemographic inequalities in comorbid insufficient physical activity and depressive symptoms among Chinese adolescents and young adults, 2016-2022. [PDF]

Sci Rep
Wang W, Huang Z, Xu B, Qian P, Yan L, Ge R.   +5 more
europepmc   +1 more source

Menopause age and hypercholesterolemia comorbidities: a region-wide retrospective cohort study in Andalusia, Spain (2016-2022). [PDF]

BMJ Open
Esteban-Medina A, de la Oliva V, Fernández Del Valle P, Sánchez A, Susin MB, Loucera C, Antiñolo G, Dopazo J.   +7 more
europepmc   +1 more source