Results 321 to 330 of about 1,146,409 (382)

A Simplified Three‐Tailed N‐Alkyl Phosphoramidate Lipid Platform Enables Inguinal Adipose‐Accumulated mRNA Delivery for Anti‐Obesity Therapy

Advanced Science, EarlyView.
This study develops an mRNA therapy encoding a long‐acting GLP‐1/FGF21 fusion protein. A three‐tailed ionizable lipid engineered three‐component lipid nanoparticle delivers the mRNA to inguinal adipose tissue. In obese mice, this targeted, dual‐hormone treatment potently reduces body weight, fat mass, presenting a localized strategy for metabolic ...
Bin Ma, Yunxuan Liu, Huijuan Zhang, Yian Fang, Yizhe Xue, Junsheng Xue, Ziqiong Jiang, Tianyan Zhou, Yanyun Hao, Fei Xie, Lei Miao   +10 more
wiley   +1 more source

Using SHAP and LIME to Explain Machine Learning Models Predicting Comorbid Depression and Stroke From Daily Dietary Nutrient Intake in a US Population-Based Study. [PDF]

Food Sci Nutr
Liu H, Wu M, Wei P, Fan H, Hou M.
europepmc   +1 more source

Comorbidity of undiagnosed mood symptoms with dementia risk in multi-regional multi-ethnic adults: evidence from epidemiological findings and plasma metabolites. [PDF]

Epidemiol Psychiatr Sci
Zhang H, Liao Y, Lin Z, Wen H, Pang T, Zhao X, Zhang W, Lou X, Chen C, Hu S, Liu Z, Xu X.   +11 more
europepmc   +1 more source

The prevalence of comorbidity among people living with HIV/AIDS in Guyana: a cross-sectional study. [PDF]

IJID Reg
Harris N, Zechariah I, Jagnarine T.
europepmc   +1 more source

Psychiatric Comorbidity and Metabolic Heterogeneity in a Multimorbid Cardiometabolic Cohort: An Exploratory Real-World Analysis. [PDF]

Healthcare (Basel)
Trandafir AL, Colasse O, Ghitea MC, Ghitea EC, Ghitea TC, Brata RD, Jurca AD.   +6 more
europepmc   +1 more source