Lenvatinib resistance poses a major challenge in advanced hepatocellular carcinoma (HCC). This study reveals that DNMT2 upregulation is a key driver, which stabilizes ACLY mRNA via m5C modification and activates the Notch signaling pathway. Crucially, combining ACLY inhibitors with lenvatinib overcomes resistance and suppresses tumors, offering a ...
Shiguang Yang +14 more
wiley +1 more source
Effectiveness of a controlled trial of nutrition education in primary school, ZELIAKIDE project: knowledge and mid-morning snack consumption. [PDF]
Vázquez-Polo M +7 more
europepmc +1 more source
Developing a psychosocial competency framework for adult and older adult acute mental health inpatient care. [PDF]
Wood L +4 more
europepmc +1 more source
Application of the Delphi methodology to forecast competencies oriented towards AI-driven disinformation detection in an expanded DigComp framework. [PDF]
Arribas CM, Arcos R, Gertrudix M.
europepmc +1 more source
Examining Predictors of Environmental Health Knowledge and Competences in a Sample of Catalan Paediatricians. [PDF]
Subiza-Pérez M +3 more
europepmc +1 more source
Fostering of social, emotional, and cognitive skills in elementary schools: the Papilio-6to9 program. [PDF]
Lechner V, Ortelbach N, Scheithauer H.
europepmc +1 more source
Digital health competences and AI beliefs as conditions for the practice of evidence-based medicine: a study of prospective physicians in Canada. [PDF]
Wagner G +3 more
europepmc +1 more source

