Results 31 to 40 of about 132,858 (314)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
On Radon Barycenters of Measures on Spaces of Measures
Известия Иркутского государственного университета: Серия "Математика", 2023 We study metrizability of compact sets in spaces of Radon measures with the weak topology. It is shown that if all compacta in a given completely regular topological space are metrizable, then every uniformly tight compact set in the space of Radon ...
V.I. Bogachev, S.N. Popova
doaj +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Compactness in Metric Spaces [PDF]
Formalized Mathematics, 2016 Summary In this article, we mainly formalize in Mizar [2] the equivalence among a few compactness definitions of metric spaces, norm spaces, and the real line. In the first section, we formalized general topological properties of metric spaces.
Nakasho, Kazuhisa +2 more
openaire +3 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Vietoris topology on spaces dominated by second countable ones
Open Mathematics, 2015 For a given space X let C(X) be the family of all compact subsets of X. A space X is dominated by a space M if X has an M-ordered compact cover, this means that there exists a family F = {FK : K ∈ C(M)} ⊂ C(X) such that ∪ F = X and K ⊂ L implies that FK ⊂
Islas Carlos, Jardon Daniel
doaj +1 more source
Properties of Fuzzy Compact Linear Operators on Fuzzy Normed Spaces
مجلة بغداد للعلوم, 2019 In this paper the definition of fuzzy normed space is recalled and its basic properties. Then the definition of fuzzy compact operator from fuzzy normed space into another fuzzy normed space is introduced after that the proof of an operator is fuzzy ...
Kider et al.
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
When is an ultracomplete space almost locally compact?
Applied General Topology, 2006 We study spaces X which have a countable outer base in βX; they are called ultracomplete in the most recent terminology. Ultracompleteness implies Cech-completeness and is implied by almost local compactness (≡having all points of non-local compactness ...
Daniel Jardón Arcos +1 more
doaj +1 more source