Results 51 to 60 of about 10,751,620 (348)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Advanced Intelligent Systems, 2022 Artificial intelligence algorithms are being adopted to analyze medical data, promising faster interpretation to support doctors’ diagnostics. The next frontier is to bring these powerful algorithms to implantable medical devices.
Zhuolin Yang +4 more
doaj +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Physics Letters B, 2017 Recent no-hair theorems have revealed the intriguing fact that horizonless stars with compact reflecting surfaces cannot support non-linear matter configurations made of scalar, vector, and tensor fields.
Shahar Hod
doaj +1 more source
The Green Dimension of a Compact City: Temperature Changes in the Urban Area of Banja Luka
Buildings, 2023 Responsible and rational urban planning is reflected in an integral and multidimensional approach to city development. Contemporary theories of sustainable and resilient urban planning support a clear vision and strategy for city development, emphasizing
Una Okilj +3 more
doaj +1 more source
Logarithmic motives with compact support
, 2023 We develop a theory of motives with compact support for logarithmic schemes over a field. Starting from the notion of finite logarithmic correspondences with compact support, we define the logarithmic motive with compact support analogous to the classical case for schemes.
openaire +2 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Compact delivery support for REDUCE
Journal of Symbolic Computation, 1995 AbstractCSL is a Lisp system specifically designed to support the REDUCE algebra system. This paper view the Lisp system upon which a Lisp-coded algebra system is coded as in effect a micro-kernel—it provides basic compilation, storage management and extended arithmetic capabilities that algebra needs, but is not much concerned with higher level ...
openaire +2 more sources
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source