Companion Blood Cells Control Ovarian Stem Cell Niche Microenvironment and Homeostasis [PDF]
The extracellular matrix plays an essential role for stem cell differentiation and niche homeostasis. Yet, the origin and mechanism of assembly of the stem cell niche microenvironment remain poorly characterized.
Véronique Van De Bor +7 more
doaj +7 more sources
A pocket companion to cell-free DNA (cfDNA) preanalytics [PDF]
The cumulative pool of cell-free DNA (cfDNA) molecules within bodily fluids represents a highly dense and multidimensional information repository. This “biological mirror” provides real-time insights into the composition, function, and dynamics of the diverse genomes within the body, enabling significant advancements in personalized molecular medicine.
Abel J, Bronkhorst, Stefan, Holdenrieder
openaire +2 more sources
Characterization of companion animal pluripotent stem cells [PDF]
AbstractPluripotent stem cells have the capacity to grow indefinitely in culture and differentiate into derivatives of the three germ layers. These properties underpin their potential to be used in regenerative medicine. Originally derived from early embryos, pluripotent stem cells can now be derived by reprogramming an adult cell back to a pluripotent
Y Z, Paterson, C, Kafarnik, D J, Guest
openaire +2 more sources
Companion cells: a diamond in the rough [PDF]
Vascular plants have developed highly specialized cells to transport nutrients and developmental signals. The differentiation process includes the degradation of multiple organelles of the sieve element cells (SEs) to facilitate transport and, as a consequence, SEs become dependent on neighboring companion cells (CCs). Despite its importance for phloem
Otero, Sofia, Helariutta, Ykä
openaire +2 more sources
Vagrant Stem Cells Draft Their Gene Companions [PDF]
In a recent issue of Nature Medicine, Ryan et al. (2010) uncover genetic modifiers of G-CSF responses by hematopoietic progenitors. The authors document a negative role of EGFR signaling and, provided an analogous pathway functions in humans, propose a potential new angle to promote clinical blood stem cell mobilization.
Bonig, Halvard, Papayannopoulou, Thalia
openaire +2 more sources
The Crucial Roles of Phloem Companion Cells in Response to Phosphorus Deficiency. [PDF]
ABSTRACTMineral deficiency is a major problem in agriculture. Plant adaption to low mineral environments involves signaling between shoots and roots, via the food transport cells, the sieve elements. However, due to the sequestered position of the sieve elements in the vascular bundles, identifying shoot‐to‐root mobile signals is challenging.
Xia C +7 more
europepmc +3 more sources
The companions: regulatory T cells and gene therapy [PDF]
SummaryUndesired immunological responses to products of therapeutic gene replacement have been obstacles to successful gene therapy. Understanding such responses of the host immune system to achieve immunological tolerance to a transferred gene product is therefore crucial.
Saman, Eghtesad +2 more
openaire +2 more sources
Differential Distribution of Proteins Expressed in Companion Cells in the Sieve Element-Companion Cell Complex of Rice Plants [PDF]
Sieve tubes are comprised of sieve elements, enucleated cells that are incapable of RNA and protein synthesis. The proteins in sieve elements are supplied from the neighboring companion cells through plasmodesmata. In rice plants, it was unclear whether or not all proteins produced in companion cells had the same distribution pattern in the sieve ...
Akari, Fukuda +9 more
openaire +2 more sources
Background Osteoarthritis (OA), the most common form of arthritic disease, results from destruction of joint cartilage and underlying bone. It affects animals, including Asian elephants (Elephas maximus) in captivity, leading to joint pain and lameness ...
Nutnicha Sirikaew +6 more
doaj +1 more source
Plasmodesmatal frequency in relation to short-distance transport and phloem loading in leaves of barley (Hordeum vulgare). Phloem is not loaded directly from the symplast [PDF]
We investigated the phloem loading pathway in barley, by determining plasmodesmatal frequencies at the electron microscope level for both intermediate and small blade bundles of mature barley leaves.
Botha, C E J, Cross, R H M
core +2 more sources

