Results 221 to 230 of about 3,893,456 (294)

Medical Device Industry Payments to Healthcare Professionals in Japan: A Descriptive Analysis of Scale, Distribution, and Transparency Based on 2019 Disclosure Data. [PDF]

J Eval Clin Pract
Hara A, Ueda M, Larkin J, Shimizu K, Endo M, Saito H, Tanimoto T, Ozaki A.   +7 more
europepmc   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Unifying Composition and Process Design: A Heterogeneous Graph Neural Network for Discovering High‐Performance Cu Alloys

Advanced Science, EarlyView.
By overcoming the fixed‐path limitations of conventional machine learning, a heterogeneous graph neural network fundamentally reconstructs material data representation. Integrating variable processing sequences with intrinsic elemental features, this framework enables exploratory optimization across high‐dimensional spaces.
Jie Yin, Qian Lei, Wei Yan, Yue Li, Tong Xie, Shuang Zhou, Chong Wang, Bram Hoex, Qiang Long, Caoyang Jiang, Min Song, Zhou Li, Zhangwei Wang   +12 more
wiley   +1 more source

Functional analysis of adrenocorticotropic-hormone-producing pituitary cells derived from human pluripotent stem cells in murine and primate models of hypopituitarism. [PDF]

Stem Cell Res Ther
Kondo T, Suga H, Watari K, Taga S, Sakakibara M, Soen M, Kawamoto I, Nishida K, Emoto R, Shiraki Y, Hiroo S, Miwata T, Hirose T, Nagata Y, Takeuchi K, Nakano T, Ikeda A, Kuwahara A, Enomoto A, Tsuchiya H, Arima H, Saito R.   +21 more
europepmc   +1 more source

Broadening Hard‐Magnet Discovery Beyond Symmetry Constraints via Unified Effective Anisotropy

Advanced Science, EarlyView.
A unified effective‐anisotropy descriptor (Keff) extends hard‐magnet screening across all seven crystal systems, beyond the uniaxial restriction of conventional searches. Machine‐learning screening of 9320 known ferromagnets and diffusion‐model generation together yield 38 rare‐earth‐free or ‐lean candidates with DFT‐validated magnetic hardness (κ > 1),
Hojae Kim, Hyeondeok Shin, Kyungju Nam, Seunghyo Noh, Donghwi Kim, Yousung Jung   +5 more
wiley   +1 more source

Can a simple geoengineering approach restore dwindling Arctic ice? [PDF]

Proc Natl Acad Sci U S A
Irfan U.
europepmc   +1 more source

One-Week Inflammatory Kinetics After First-Line Nivolumab Plus Ipilimumab in Metastatic Renal Cell Carcinoma: A Multicenter Landmark Analysis. [PDF]

Target Oncol
Inoue T, Numakura K, Osawa T, Naito S, Ishihara T, Ohba K, Ueda K, Sekine Y, Oki M, Naito H, Miyata H, Kikuchi H, Kobayashi S, Narita S, Tsuchiya N, Sugimoto M, Igawa T, Shin T.   +17 more
europepmc   +1 more source

Age-based stereotypes in hiring and training: how digitalization and labor shortages reshape employer decisions. [PDF]

Eur J Ageing
Heyer P, Schmitz W, Weis K.
europepmc   +1 more source

Taking stock of most-favored nation deals: how have markets reacted? [PDF]

Health Aff Sch
Kirson NY, Dooley JM, Ge Z, Chandra A.
europepmc   +1 more source