Results 41 to 50 of about 2,883,628 (260)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Is it worth the hype? Influence of Artificial Intelligence efforts on key financial company metrics

Copernican Journal of Finance & Accounting
Artificial Intelligence poses a consortium of multiple digital technologies able to perform tasks which were thought about that they can only be done by humans.
Daniel Maier
doaj   +1 more source

Structural capital, innovation capability, and company performance in technology-based colombian firms

Management Letters/Cuadernos de Gestión, 2015
In today’s economy, innovation is considered to be one of the main driving forces behind business competitiveness, if not the most relevant one. Traditionally, the study of innovation has been addressed from different perspectives.
Nekane Aramburu, Josune Sáenz, Carlos E. Blanco   +2 more
doaj   +1 more source

Evaluating demand driven MRP: a case based simulated study [PDF]

, 2015
This study evaluates the assumption underpinning Material Requirements Planning (MRP), buffer management and DDMRP before analysing the case company and evaluating the potential benefits, utilizing simulated data from the existing ERP system. The purpose
Ihme, M, Stratton, R
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Boom Potential Energy Regeneration Method for Hybrid Hydraulic Excavators

IEEE Access
Affected by complex operating conditions and working characteristics of the hydraulic system, hydraulic excavators suffer from large energy consumption, low energy utilization rate, and poor emissions for a long time.
Jianxin Zhu, Chao Shen, Qinghua He, Saibai Li, Peng Dai, Xiang Li   +5 more
doaj   +1 more source

ESG REPORTING IN ROMANIA: ASSESSING SUSTAINABILITY PRACTICES AND THEIR FINANCIAL IMPACT ON BET-LISTED COMPANIES [PDF]

Oradea Journal of Business and Economics
In recent years, ESG reporting in Romania has gained increasing relevance, driven by both regulatory developments at the European level and growing investor demand for transparency regarding corporate sustainability practices. This paper investigates the
Raul-Constantin BUCUREAN, Roxana-Nadina BUCUREAN (ROIBAN)   +1 more
doaj   +1 more source

Pengaruh Motivasi, Kompensasi Dan Jenjang Karier Yang Tersedia Terhadap Kinerja Karyawan [PDF]

, 2012
This purpose of this research is to understand the influence of motivation, compensation, and availability of career ladder to employee performance. This research also gives a description of similar researches especially research that also related ...
., Melisa
core  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source