Results 21 to 30 of about 548,215 (253)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

THE EFFECT OF COMPANY SIZE, DEBT POLICY, AND PROFITABILITY ON COMPANY

open access: yesMORFAI JOURNAL, 2022
The purpose of this study is to test and analyze the effect of Company Size on Firm Value, to test and analyze Debt Policy on Firm Value, to test and analyze Profitability on Firm Value and to test and analyze the effect of Company Size, Debt Policy and Profitability on Firm Value. in Real Estate Companies listed on the IDX. The population used in this
Masta Sembiring, Trie Meutia Defi
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Confirmation Bias in Software Development and Testing: An Analysis of the Effects of Company Size, Experience and Reasoning Skills [PDF]

open access: yes, 2010
During all levels of software testing, the goal should be to fail the code to discover software defects and hence to increase software quality. However, software developers and testers are more likely to choose positive tests rather than negative ones ...
Aslan, Berna, Calikli, Gul, Bener, Ayse
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

PENGARUH COMPANY SIZE, COMPANY AGES, PROFITABILITY, DAN LEVERAGE TERHADAP CSR DISCLOSURES PADA KELOMPOK PERUSAHAAN PROPERTI DAN REAL ESTATE YANG TERDAFTAR DI BEI

open access: yes, 2013
The primary objective of this research is to learn the effect of company size, company ages, profitability, and leverage variables on corporate social responsibility disclosures variable, either simultaneously or partially.
Sunaryo, S. (Sunaryo)   +2 more
core   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler   +20 more
wiley   +1 more source

The Influence Of Profitability, Liquidity, Company Growth, Capital Structure, And Company Size On Company Value (Investment Trading Subsector Company) [PDF]

open access: yes, 2022
This study aims to analyze Profitability, Liquidity, Company Growth, Capital Structure and Company Size to Company Value. This research is a causal research with the independent variables Profitability, Liquidity, Company Growth, Capital Structure and ...
Hidayat, Amswie Irfan
core  

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito   +14 more
wiley   +1 more source

THE EFFECT OF PROFITABILITY, SOLVABILITY AND COMPANY SIZE ON THE COMPANY VALUE [PDF]

open access: yesJurnal Akuntansi Trisakti, 2019
This study aims to determine the effect of Profitability, Solvability, and Company Size on Company Values on LQ-45 companies for the period 2015-2017. As many as 99 companies registered in the LQ-45 index were sampled. This study chooses the purposive sampling method to obtain the data.
Taufan Taufan   +2 more
openaire   +1 more source

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