Results 1 to 10 of about 556,273 (328)

Detection and quantitation of host cell proteins in monoclonal antibody drug products using automated sample preparation and data-independent acquisition LC-MS/MS

Journal of Pharmaceutical Analysis, 2021
Ensuring the removal of host cell proteins (HCPs) during downstream processing of recombinant proteins such as monoclonal antibodies (mAbs) remains a challenge. Since residual HCPs might affect product stability or safety, constant monitoring is required
Lisa Strasser, Giorgio Oliviero, Craig Jakes, Izabela Zaborowska, Patrick Floris, Meire Ribeiro da Silva, Florian Füssl, Sara Carillo, Jonathan Bones   +8 more
doaj   +1 more source

IFRS meets the realities of a post-communist Balkan State [PDF]

Contabilitate şi Informatică de Gestiune, 2022
Research Question: How will the Substance-over-Form (SoF) ‘organism’ survive, mutate and develop in a new and unfamiliar ‘environment’? Motivation: Our study is motivated and inspired from a previous study published by Alexander et al.
David Alexander, Jonida Carungu, Stefania Vignini   +2 more
doaj   +1 more source

Proteomic Profiling of IgG1 Producing CHO Cells Using LC/LC-SPS-MS3: The Effects of Bioprocessing Conditions on Productivity and Product Quality

Frontiers in Bioengineering and Biotechnology, 2021
The biopharmaceutical market is dominated by monoclonal antibodies, the majority of which are produced in Chinese hamster ovary (CHO) cell lines.
Lisa Strasser, Amy Farrell, Jenny T. C. Ho, Kai Scheffler, Ken Cook, Patrick Pankert, Peter Mowlds, Rosa Viner, Barry L. Karger, Jonathan Bones   +9 more
doaj   +1 more source

Paper-based and computer-based admission tests for medicine – are they equivalent?

Frontiers in Education, 2023
Admission tests are among the most widespread and effective criteria for student selection in medicine in Germany. As such, the Test for Medical Studies (TMS) and the Hamburg Assessment Test for Medicine, Natural Sciences (HAM-Nat) are two major ...
Malvin Escher, Malvin Escher, Daniel Weppert, Dorothee Amelung, Thorben Huelmann, Stephan Stegt, Johanna Hissbach   +6 more
doaj   +1 more source

CAR Gene Delivery by T‐cell Targeted Lentiviral Vectors is Enhanced by Rapamycin Induced Reduction of Antiviral Mechanisms

Advanced Science, 2023
Lentiviral vectors (LV) have become the dominant tool for stable gene transfer into lymphocytes including chimeric antigen receptor (CAR) gene delivery to T cells, a major breakthrough in cancer therapy.
Filippos T Charitidis, Elham Adabi, Naphang Ho, Angela H Braun, Ciara Tierney, Lisa Strasser, Frederic B Thalheimer, Liam Childs, Jonathan Bones, Colin Clarke, Christian J Buchholz   +10 more
doaj   +1 more source

Comparing different domains of analysis for the characterisation of N-glycans on monoclonal antibodies

Journal of Pharmaceutical Analysis, 2020
With the size of the biopharmaceutical market exponentially increasing, there is an aligned growth in the importance of data-rich analyses, not only to assess drug product safety but also to assist drug development driven by the deeper understanding of ...
Sara Carillo, Raquel Pérez-Robles, Craig Jakes, Meire Ribeiro da Silva, Silvia Millán Martín, Amy Farrell, Natalia Navas, Jonathan Bones   +7 more
doaj   +1 more source

HOW ARE THE CONCEPTUAL FRAMEWORK HYPOTHESES REFLECTED INTO PRACTICE? A SHORT REVIEW OF THE CURRENT LITERATURE. [PDF]

Annals of the University of Oradea: Economic Science, 2023
The IFRS implementation has marked an important milestone in the history of accounting. Since the beginning, there have been both advocates and critics, debating whether the initial objectives were, in fact, met in practice.
Antonia Cosmina GIUGLEA
doaj   +1 more source

Comparability of accelerometry outcomes across popular metrics and widespread sensor positions. [PDF]

PLoS One
Olfermann R, Ebner-Priemer U, Reichert M, Giurgiu M.   +3 more
europepmc   +2 more sources

Quality comparability assessment of a SARS-CoV-2-neutralizing antibody across transient, mini-pool-derived and single-clone CHO cells

mAbs, 2022
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered a serious public health crisis worldwide, and considering the novelty of the disease, preventative and therapeutic measures alike are urgently needed.
Gangling Xu, Chuanfei Yu, Wenbo Wang, Cexiong Fu, Hongchuan Liu, Yanping Zhu, Yuan Li, Chunyu Liu, Zhihao Fu, Gang Wu, Meng Li, Sha Guo, Xiaojuan Yu, Jialiang Du, Yalan Yang, Maoqin Duan, Yongfei Cui, Hui Feng, Lan Wang   +18 more
doaj   +1 more source

The Relationship between Financial Statements Comparability with Stock Price in Formativeness about Future Earnings [PDF]

مطالعات تجربی حسابداری مالی, 2016
The present research deals with explaining the relationship betweenfinancial statements comparability and the stock price informativeness regarding the future earnings as well as explaining therole of the financial statements comparability in reflecting ...
F. Mehrvarz, M. Marfou
doaj   +1 more source