Results 91 to 100 of about 7,474,429 (290)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Reading the Word and the World: Overstanding Literacy in Aboriginal and Chinese Classrooms

open access: yesEducation Sciences
This qualitative comparative case study examines how culturally grounded philosophies of education shape the teaching and learning of reading in two cross-cultural contexts—an Aboriginal Australian classroom and urban Chinese elementary schools.
Gui Ying (Annie) Yang-Heim
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

A Comparative Study of Gender Language in Pride and Prejudice and Frankenstein Novels [PDF]

open access: yes, 2013
This study deals with the similarities and differences of gender language expressed in Pride and Prejudice and Frankenstein Novels. The object of this study is to find out the similarities and differences of gender language which are expressed in Pride ...
Silitonga, S. (Safriana)   +1 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Papaya Development Model As A Competitive Local Superior Commodity

open access: yesJurnal Ekonomi Pembangunan: Kajian Masalah Ekonomi dan Pembangunan, 2014
The aim of this research is to study the comparative advantage and papaya competitive and to design its development model by using the approach of local base agriculture development. This research uses survey method.
Reny Sukmawani   +3 more
doaj  

A Better Way to Generate and Use Comparative-Effectiveness Research [PDF]

open access: yes, 2009
President Barack Obama, former U.S. Senate majority leader Tom Daschle, and others propose a new government agency that would evaluate the relative effectiveness of medical treatments. The need for "comparative-effectiveness research" is great.
Michael F. Cannon
core  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The contingent nature of proximity voting: unravelling the interplay of party issue polarization and voters’ positional extremity

open access: yesPolitical Research Exchange
Extant research argues that party issue polarization increases voters’ propensity to engage in proximity voting, but evidence is mixed. We argue that the extremity of voters’ issue positions affects the extent to which party polarization increases their ...
Andreas C. Goldberg, Jonas Lefevere
doaj   +1 more source

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