Results 101 to 110 of about 3,421,754 (293)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Breaks in the Chain of Comparative Advantage [PDF]

open access: yes
chain; comparative ...
Choi, E. Kwan, Thompson, Henry
core  

LA CONFIGURATION/ LA RECONFIGURATION DE L’IMAGE URBAINE DANS LA CONCURRENCE INTERURBAINE. LE CAS DES VILLES DE BRAȘOV ET DE CONSTANȚA [PDF]

open access: yesDiversitate si Identitate Culturala in Europa, 2013
In the context of increasingly accentuated globalization, the present cities are forced, in an elegant manner, to act individually in order to ensure economic, social and cultural development.
Teodora Mădălina PAFTALĂ
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Comparative advantage of organic wheat production in the Western Cape [PDF]

open access: yes
In a context in which the framework of agricultural policy and business is changing radically the objective of the government and farmers should be to support the development of systems that look likely to be winners in the future. As a result this paper
Mendes, E., Vink, Nick, Mahlanza, B.
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

REVEALED COMPARATIVE ADVANTAGE AND THE MEASUREMENT OF INTERNATIONAL COMPETITIVENESS FOR AGRICULTURAL COMMODITIES: AN EMPIRICAL ANALYSIS OF WOOL EXPORTERS [PDF]

open access: yes
Trade liberalization and laissez-faire economics are altering the structure of agricultural production and trade. The principle of comparative advantage, a classic tenet of economics, is a useful tool for understanding the future of world agriculture ...
Whipple, Glen D.   +2 more
core  

Comparative advantage and caste evolution

open access: yesEvolution, 2020
Most of the theory for the evolution of caste specialization in social insects assumes that increased efficiency in worker labor leads to specialization and increased worker efficiency gives colonies with behavioral specialists an advantage. However, there are an increasing number of studies that show that the task specialists within social insect ...
openaire   +3 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

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