Results 131 to 140 of about 3,421,754 (293)
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
International Trade Arising from Wage Differences
Lahore Journal of EconomicsThis paper analyzes how trade can develop between low and high wage countries when there is free trade and when there is protection. In particular, the paper focuses on Pakistani industrial development from the 1950’s and how standard international ...
Sikander Rahim
doaj
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
ВІДНОСНА ПЕРЕВАГА ЯК ГОЛОВНИЙ ФАКТОР ЗАВОЮВАННЯ АБСОЛЮТНОЇ ПЕРЕВАГИ У ВІЙСЬКОВОМУ КОНФЛІКТІ
Sučasnì Informacìjnì Tehnologìï u Sferì Bezpeki ta Oboroni, 2015 Ця стаття розкриває важливість здобуття переваги на підготовчій та початковій стадіях військового конфлікту (відносної переваги) для здобуття абсолютної переваги в цілому, що, у свою чергу, є необхідною умовою для отримання перемоги в збройному конфлікті.
Andrey V. Revutckyi
doaj
Open AgricultureThis study evaluates the competitiveness of 12 leading coffee-producing nations – Brazil, Colombia, Ethiopia, Guatemala, Honduras, India, Indonesia, Mexico, Nicaragua, Peru, Uganda, and Vietnam – by analyzing their comparative advantages across five ...
Ma’ruf Muhammad Imam +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Comparative and Competitive Advantage of the Shrimp Industry in Mekong River Delta, Vietnam [PDF]
Given the growing prominence of Vietnam's fishery products in the world market, this study examines data on shrimp aquaculture in the country, as practiced through intensive and semi-intensive methods, in two provinces in the Mekong River Delta region ...
Nguyen Tuan Kiet, Zenaida M. Sumalde
core
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source