Results 41 to 50 of about 321,975 (256)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Implications and Competitiveness of Regions on Regional Development of Central Java
Jurnal Ekonomi Pembangunan: Kajian Masalah Ekonomi dan Pembangunan, 2014 Regional Competitiveness be one of the issues in regional development policy since the enactment of regional autonomy. Based on the results of the efficiency analysis found 11 areas of the city and district have the efficiency and 4 districts do not have
Daryono Soebagiyo
doaj
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Inferring comparative advantage via entropy maximization
Journal of Physics: Complexity, 2023 We revise the procedure proposed by Balassa to infer comparative advantage, which is a standard tool in Economics to analyze specialization (of countries, regions, etc). Balassa’s approach compares a country’s export of a given product with what would be
Matteo Bruno +4 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Avantaje competitive în teritorii identitar-productive din spaţiul rural românesc – cazul zonelor viticole [PDF]
Urbanism. Arhitectura. Constructii, 2010 The analysis focused on shaping and describing some identity-producing categories of territories, focusing on those with a potential for the wine industry, starting from the premise according to which natural resources of a territory could not only ...
Alina Chicoş
doaj
Investigation on comparative advantage and export stability performance of Iran's forest products [PDF]
تحقیقات جنگل و صنوبر ایران, 2014 Islamic Republic of Iran's forest products export market at time interval of 1970 to 2009 was investigated, using comparative advantage indices. Based on application of Revealed Comparative Advantage (RCA) and Revealed Symmetric Comparative Advantage ...
Hamid Amirnejad, Alireza Alipour
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Where Is American Agriculture in Its "Life Cycle"?
Journal of Agricultural and Resource Economics, 2003 The increasing globalization of agricultural markets in recent decades appears to be changing the economics of the American production agriculture sector, reducing its economic importance and raising questions about its life cycle. This study contributes
Steven C. Blank
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source