Results 111 to 120 of about 14,378,408 (311)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Brain structural plasticity in large-brained mammals: Not only narrowing roads
Neural Regeneration ResearchThe capacity of the central nervous system for structural plasticity and regeneration is commonly believed to show a decreasing progression from “small and simple” brains to the larger, more complex brains of mammals.
Marco Ghibaudi +2 more
doaj +1 more source
Comparative literature in an age of Globalization: Une réponse
, 2011 Comparative literature in an age of Globalization: Une ...
DE HUENEN, ROLAND
core
Comparative Literature in Canada: A Testimony from Below [PDF]
, 2014 A personal account of Valente\u27s "academic trajectory from Brazil to Canada, [which] asks to be understood as an analogy of the current status of Comparative Canadian Literature.
Valente, Andrea C.
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Non-Verbal Behavior as a Marker of Altered States of Consciousness in a Literary Piece
RUDN Journal of Language Studies, Semiotics and SemanticsThe problem of altered states of consciousness from linguistic angle is relevant. Attention is focused on the ways in which altered states of consciousness are reflected in a literary piece.
Vera V. Ganina, Faina I. Kartashkova
doaj +1 more source
, 2011 Responses to Comparative Literature in an Age of Globalization: A brief Note / Réponses à Comparative Literature in an Age of Globalization: Note ...
HART, JONATHAN L.
core
Neither Here nor There: The (Non-)Geographical Futures of Comparative Literature [PDF]
, 2014 The introduction to the special issue "(Non-)Geographical Futures of Comparative Literature", part of a joint project between CRCL/RCLC and Peking University\u27s Journal of Comparative Literature and World ...
Hui, Zhang, Fried, Daniel
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source