Results 91 to 100 of about 7,918,346 (306)

Two Fluorescent Probes for Recognition of Acetylcholinesterase: Design, Synthesis, and Comparative Evaluation

Molecules
In this study, two “on–off” probes (BF2-cur-Ben and BF2-cur-But) recognizing acetylcholinesterase (AChE) were designed and synthesized. The obtained probes can achieve recognition of AChE with good selectivity and pH-independence with a linear range of 0.
Xia Lin, Qingyuan Yi, Binyang Qing, Weisen Lan, Fangcheng Jiang, Zefeng Lai, Jijun Huang, Qing Liu, Jimin Jiang, Mian Wang, Lianjia Zou, Xinbi Huang, Jianyi Wang   +12 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Comparative evaluation of quality management practices in the public and private hospitals in Visakhapatnam District: An original research

Journal of Pharmacy and Bioallied Sciences
Background: In the Visakhapatnam District, this study compares the quality management procedures used by public and private hospitals. Knowing how these practices are similar and different from one another can help inform policy decisions and improve the
Rahul V C. Tiwari, Sandesh K Sharma, Sujit R Sahoo, Srujan K Velthuru, Jeevan Matada Basavarajaiah, Madiha Kazi, Heena Dixit   +6 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Estimation of the Saber 11 Test: Review of Structural Changes between 2014 and 2022 at the General Santander Educational Institution

RHS Revista Humanismo y Sociedad
Standardized assessments, such as the Saber 11 test, play a crucial role in both individual and institutional decision-making in the educational field.
Jorge Enrique Díaz Pinzón
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Internsʼ Self-evaluations Compared with Their Facultyʼs Evaluations

Academic Medicine, 2000
The accuracy with which individuals evaluate and judge their knowledge and skills is an important component of adult and life-long learning. This study compared the evaluations that interns made of themselves with those made by their faculty.
S C, Zonia, M, Stommel
openaire   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Analysis of Research Excellence Assessment Frameworks and Providing Policy Requirements for Iran [PDF]

نشریه مطالعات دانش‌پژوهی
Purpose: Many countries have developed and implemented research excellence frameworks  tailored to their specific social, cultural, and academic context.
Ghasem Azadi
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source