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Comparative Genomic Hybridization
Current Protocols in Human Genetics, 1995AbstractComparative Genomic Hybridization (CGH) is a powerful molecular cytogenetic technique that permits assessment of DNA copy number on a genome‐wide scale. Of note, this methodology uses tumor DNA as a probe for fluorescence in situ hybridization (FISH) to normal metaphase chromosomes and does not require dividing cells from the tumor specimen ...
Daniel Pinkel +4 more
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Novel applications of array comparative genomic hybridization in molecular diagnostics
Expert Review of Molecular Diagnostics, 2018Introduction: In 2004, the implementation of array comparative genomic hybridization (array comparative genome hybridization [CGH]) into clinical practice marked a new milestone for genetic diagnosis.
S. Cheung, W. Bi
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Comparative Genomic Hybridization
Current Protocols in Cell Biology, 2004AbstractComparative genomic hybridization (CGH) is a screening method based on fluorescence in situ hybridization (FISH). In contrast to conventional FISH, the metaphase target is derived from a normal peripheral blood lymphocyte culture. This target is hybridized to the test or tumor DNA, which is labeled/detected by one fluorochrome (i.e., green ...
Jane Bayani, Jeremy A. Squire
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Comparative genomic hybridization in ganglioneuroblastomas
Cancer Genetics and Cytogenetics, 2002The ganglioneuroblastoma are rare lesions with widespread neuronal differentiation that have been classified as intermediate stages between neuroblastoma and ganglioneuroma. To identify overall chromosome aberrations in ganglioneuroblastoma, we performed comparative genomic hybridization.
Toraman A.D. +4 more
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Genome screening by comparative genomic hybridization
Trends in Genetics, 1997Comparative genomic hybridization (CGH) provides a molecular cytogenetic approach for genome-wide scanning of differences in DNA sequence copy number. The technique is now attracting wide-spread interest, especially among cancer researchers. The rapidly expanding database of CGH publications already covers about 1500 tumors and is beginning to reveal ...
Olli-P. Kallioniemi +4 more
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Comparative Genomic Hybridization: Practical Guidelines
Diagnostic Molecular Pathology, 2002Comparative genomic hybridization (CGH) is a technique used to identify copy number changes throughout a genome. Until now, hundreds of CGH studies have been published reporting chromosomal imbalances in a large variety of human neoplasms. Additionally, technical improvements of specific steps in a CGH experiment and reviews on the technique have ...
Jeuken, J.W.M. +2 more
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Comparative Genomic Hybridization
2003Comparative genomic hybridization (CGH) is a molecular cytogenetic technique used to screen the entire genome for gains and losses of genetic material (1). It is being used increasingly in the study of cancer genetics to identify genes important in the initiation, progression, and, of particular relevance here, metastasis of tumors (2-4).One of the ...
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Comparative genomic hybridization: Uses and limitations
Seminars in Hematology, 2000Comparative genomic hybridization (CGH) has contributed significantly to the current knowledge of genomic alterations in hematologic malignancies. Characteristic patterns of genomic imbalances not only have confirmed recent classification schemes in non-Hodgkin's lymphoma, but they provide a basis for the successful identification of genes with ...
Stefan Joos +3 more
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Array Comparative Genomic Hybridization in Osteosarcoma [PDF]
, 2013 Osteosarcoma, the most frequent primary bone tumor, is a malignant mesenchymal sarcoma with a peak incidence in young children and adolescents. Left untreated, it progresses relentlessly to local and systemic disease, ultimately leading to death within months.
Maria Zielenska +3 more
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Comparative genomic hybridization analysis of hepatoblastomas
Genes, Chromosomes and Cancer, 2000Prior cytogenetic analyses of hepatoblastomas have shown the most common recurring abnormalities to be trisomy for chromosomes 2 and 20, and a recurrent translocation involving chromosomes 1 and 4 identified in a minority of cases. Four cases have shown double minute chromosomes, which provide cytogenetic evidence for gene amplification, although no ...
Barbara A. Baker +3 more
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