Results 341 to 350 of about 265,128 (376)

Comparative Genomic Hybridization Technique

2003
Screening for chromosomal changes in solid tumors was long hindered by methodological problems encountered in standard cytogenetic analysis. Comparative genomic hybridization (CGH), a technique that emerged in 1992 (1) has proved to be a powerful tool for molecular cytogenetic analysis of neoplasms.
Sakari Knuutila, Wael El-Rifai
openaire   +3 more sources

Oligonucleotide Array Comparative Genomic Hybridization

2007
The array CGH technique (array comparative genome hybridization) has been developed to detect chromosomal copy number changes on a genome-wide and/or high-resolution scale. Here, we present validated protocols using in-house spotted oligonucleotide libraries for array CGH.
Van Den Ijssel, Paul, Ylstra, Bauke
openaire   +4 more sources

Comparative Genomic Hybridization

2002
Comparative genomic hybridization (CGH) allows the entire genome of an organism to be scanned for relative changes in DNA copy number (copy number aberrations) (1–3) in a single experiment. Standard CGH can detect aneuploidies, deletions, and unbalanced translocations at a resolution of 5–10 megabases.
Burt G. Feuerstein, Gregg Magrane, Malgorzata Pellarin, Yuichi Hirose   +3 more
openaire   +2 more sources

Comparative genomic hybridization and prenatal diagnosis

Current Opinion in Obstetrics & Gynecology, 2006
Microarray-based comparative genomic hybridization (array-CGH) which detects aneuploidies and submicroscopic deletions and duplications in one assay is now offered for genetic diagnosis in children and adults. Its application to prenatal diagnosis is still limited, but very promising.
Arthur L. Beaudet, Ignatia B. Van den Veyver   +1 more
openaire   +3 more sources

Fluorescence In Situ Hybridization and Comparative Genomic Hybridization

2006
This chapter discusses the complementary methodologies of fluorescence in situ hybridization and comparative genomic hybridization. Fluorescence in situ hybridization uses fluorescently labeled DNA probes (whole chromosomes, centromere, or locus-specific sequences) to visualize complementary DNA sequences in the target DNA (metaphase chromosomes or ...
Patricia Gorman, Rebecca Roylance
openaire   +3 more sources

Quantitative analysis of comparative genomic hybridization

Cytometry, 1995
AbstractComparative genomic hybridization (CGH) is a new molecular cytogenetic method for the detection of chromosomal imbalances. Following cohybridization of DNA prepared from a sample to be studied and control DNA to normal metaphase spreads, probes are detected via different fluorochromes.
Thomas Cremer, Thomas Ried, Michael R. Speicher, Stanislas du Manoir, Stefan Joos, Evelin Schröck, Peter Lichter, Martin Bentz   +7 more
openaire   +3 more sources

Comparative genomic hybridization in epithelioid sarcoma

British Journal of Dermatology, 2004
Epithelioid sarcoma is a rare mesenchymal neoplasm of unknown histogenesis. Data on genome-wide surveys for chromosomal aberrations in epithelioid sarcoma are limited.To investigate genetic aberrations in epithelioid sarcoma.We analysed seven cases of epithelioid sarcoma (classic type, three cases and proximal type, four cases) by comparative genomic ...
Jai-Kyoung Koh, Mi-Woo Lee, Seung Seog Han, Kee-Chan Moon, Jee Kj, Gyungyub Gong, Choi Jh   +6 more
openaire   +2 more sources

In Situ Hybridization and Comparative Genomic Hybridization

1997
Quantitative and structural aberrations in the genomic content of malignancies or premalignant lesions are in many cases correlated with the prognosis of the disease. Since such genetic changes are central to the initiation and progression of neoplasms, techniques have been developed for their detection and characterization.
Christina E.M. Voorter, Frans C. S. Ramaekers, Ernst J. M. Speel, Anton H. N. Hopman   +3 more
openaire   +2 more sources

Comparative Genomic Hybridization on BAC Arrays

2009
Alterations in genomic DNA are a key feature of many constitutional disorders and cancer. The discovery of the underlying regions of gene dosage has thus been essential in dissecting complex disease phenotypes and identifying targets for therapeutic intervention and diagnostic testing.
Bradley P. Coe, Wan L. Lam, Raj Chari, William W. Lockwood   +3 more
openaire   +3 more sources

Comparative genomic hybridization analysis of craniopharyngiomas

Journal of Neurosurgery, 2003
Object. Craniopharyngioma is the most common childhood brain tumor and is thought to arise from embryonic remnants of the Rathke pouch. Some craniopharyngiomas are monoclonal in origin and hence presumably harbor somatic genetic alterations, although the precise molecular mechanisms involved in craniopharyngioma development are unknown.
Shlomit Rienstein, Eitan Friedman, David Pilzer, Eric F. Adams, Boleslaw Goldman, Ayala Aviram Goldring   +5 more
openaire   +3 more sources