Results 31 to 40 of about 174,992 (335)

Comparative genomic hybridization of postirradiation sarcomas [PDF]

Cancer, 2001
Radiotherapy is a known risk factor for sarcoma development. Postirradiation sarcomas arise within the radiation field after a latency period of several years and usually are highly malignant. Very little is yet known about their genetic changes.Twenty-seven postirradiation sarcomas were analyzed by comparative genomic hybridization, which allows ...
Y. Sakari Knuutila, Y. Sakari Knuutila, Maija Tarkkanen, Maija Tarkkanen, Fredrik Mertens, A. Inkeri Elomaa, Markku Miettinen, Erkki Tukiainen, Carl Blomqvist, Nils Mandahl, Marcelo L. Larramendy, Marcelo L. Larramendy, Marcelo L. Larramendy, Tom Wiklund, Martti Virolainen   +14 more
openaire   +3 more sources

Chromosomal imbalances detected in primary bone tumors by comparative genomic hybridization and interphase fluorescence in situ hybridization

Genetics and Molecular Biology, 2003
We applied a combination of comparative genomic hybridization (CGH) and fluorescence in situ hybridization (FISH), to characterize the genetic aberrations in three osteosarcomas (OS) and one Ewing's sarcoma. CGH identified recurrent chromosomal losses at
Marcelo Razera Baruffi, Edgard Edward Engel, Jeremy Andrew Squire, Luis Gonzaga Tone, Silvia Regina Rogatto   +4 more
doaj   +1 more source

Comparative genomic hybridization identifies virulence differences in Streptococcus suis. [PDF]

PLoS ONE, 2014
Streptococcus suis is an important zoonotic pathogen. However, identification of virulent S. suis strains is complicated because of the high diversity of the species. Here we evaluated the genetic difference among S.
Han Zheng, Ruiting Lan, Xiao Zheng, Zhigang Cui, Zhijie Liu, Xuemei Bai, Shaobo Ji, Marcelo Gottschalk, Jianguo Xu   +8 more
doaj   +1 more source

Losses of chromosomes 1p and 3q are early genetic events in the development of sporadic pheochromocytomas [PDF]

, 2000
Despite several loss of heterozygosity studies, a comprehensive genomic survey of pheochromocytomas is still lacking. To identify DNA copy number changes which might be important in tumor development and progression and which may ...
Bonjer, H.J. (Jaap), Dannenberg, H. (Hilde), Dinjens, W.N.M. (Winand), Harst, E. (Erwin) van der, Heitz, P.U., Komminoth, P. (Paul), Krijger, R.R. (Ronald) de, Mooi, W.J. (Wolter), Roth, J. (Joost), Saremaslani, P., Speel, E.J. (Ernst-Jan), Zhao, J. (Jinkou)   +11 more
core   +2 more sources

Genomic complexity in pediatric synovial sarcomas (Synobio study): the European pediatric soft tissue sarcoma group (EpSSG) experience

Cancer Medicine, 2018
A genomic index (GI) tool using array comparative genomic hybridization (aCGH) on tumor cells has emerged as independent prognostic factor associated with the risk of metastatic relapse in synovial sarcoma (SS).
Daniel Orbach, Véronique Mosseri, Daniel Pissaloux, Gaelle Pierron, Bernadette Brennan, Andrea Ferrari, Frederic Chibon, Gianni Bisogno, Gian Luca De Salvo, Camille Chakiba, Nadège Corradini, Véronique Minard‐Colin, Anna Kelsey, Dominique Ranchère‐Vince   +13 more
doaj   +1 more source

Genomic alterations in primary gastric adenocarcinomas correlate with clinicopathological characteristics and survival. [PDF]

, 2004
Background & aimsPathogenesis of gastric cancer is driven by an accumulation of genetic changes that to a large extent occur at the chromosomal level. In order to investigate the patterns of chromosomal aberrations in gastric carcinomas, we performed
Albertson, Donna, Kuipers, Ernst J, Meijer, Gerrit A, Meuwissen, Stefan GM, Pinkel, Daniel, Postma, Cindy, Snijders, Antoine M, Weiss, Marjan M   +7 more
core   +3 more sources

High Resolution Comparative Genomic Hybridization Detects 7–8 Megabasepair Deletion in PCR Amplified DNA1

Analytical Cellular Pathology, 2001
We investigated if any change in spatial resolution of comparative genomic hybridization analysis could be detected when using DNA amplified by degenerate oligonucleotide primed PCR (DOP‐PCR) as opposed to the use of unamplified DNA.
Jacob Larsen, Anne Marie Ottesen, Maria Kirchhoff, Claes Lundsteen, Jørgen K. Larsen   +4 more
doaj   +1 more source

A novel deletion in 2q24.1q24.2 in a girl with mental retardation and generalized hypotonia: a case report

Molecular Cytogenetics, 2012
Background Chromosomal imbalances, recognized as the major cause of mental retardation, are often due to submicroscopic deletions or duplications not evidenced by conventional cytogenetic methods.
Palumbo Orazio, Palumbo Pietro, Palladino Teresa, Stallone Raffaella, Zelante Leopoldo, Carella Massimo   +5 more
doaj   +1 more source

Identification of genomic alterations in pancreatic cancer using array-based comparative genomic hybridization. [PDF]

PLoS ONE, 2014
BACKGROUND: Genomic aberration is a common feature of human cancers and also is one of the basic mechanisms that lead to overexpression of oncogenes and underexpression of tumor suppressor genes.
Jian-Wei Liang, Zhi-Zhou Shi, Tian-Yun Shen, Xu Che, Zheng Wang, Su-Sheng Shi, Xin Xu, Yan Cai, Ping Zhao, Cheng-Feng Wang, Zhi-Xiang Zhou, Ming-Rong Wang   +11 more
doaj   +1 more source

Genomic Profiling by Array Comparative Genomic Hybridization Reveals Novel DNA Copy Number Changes in Breast Phyllodes Tumours

Cellular Oncology, 2009
Breast phyllodes tumour (PT) is a rare fibroepithelial tumour. The genetic alterations contributing to its tumorigenesis are largely unknown. To identify genomic regions involved in pathogenesis and progression of PTs we obtained genome-wide copy number ...
Arno Kuijper, Antoine M. Snijders, Els M. J. J. Berns, Vibeke Kuenen-Boumeester, Elsken van der Wall, Donna G. Albertson, Paul J. van Diest   +6 more
doaj   +1 more source