Results 141 to 150 of about 2,296,672 (303)

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

A Magneto‐Mechanically Activated Nerve Guidance Conduit Promotes Peripheral Nerve Regeneration via TIMP1‐Mediated Membrane Tension Transfer

Advanced Functional Materials, EarlyView.
This study presents a magneto‐mechanical strategy that incorporates FP@MSCs into an aligned PCL/GelMA nerve guidance conduit. Magnetic stimulation increases membrane tension in FP@MSCs, triggering cytoskeletal remodeling, Schwann cell‐like differentiation, and TIMP1 secretion. TIMP1 activates ITGB1/CD63–FAK signaling in NE‐4C cells, increasing membrane
Xinyu Zhu, Yumin Wu, Xiang Gao, Tianlu Wang, Wanting Jia, Xueying Mei, Huanzhong Ji, Zongxi Wu, Yujie Liang, Xiang Li, Kan Li, Jingyuan Li, Guangsen Zheng, Guiqing Liao, Siyong Gao   +14 more
wiley   +1 more source

Bioinspired Hydrogels with Broadly Programmable Mechanics for Soft‐Tissue Interfaces

Advanced Functional Materials, EarlyView.
Sea cucumber‐inspired gelatin hydrogels are formed by directional freezing and mechanically programmed through subsequent ionic treatment. Multiscale characterization and modeling link ion‐regulated chain interactions to directional load transfer within the aligned hierarchical architecture.
Youchao Teng, TzuChun Chung, Katpady Akhil Tantry, Siyu Wu, Jing Tian, Yunqi Cui, Lanyu Li, Yongzan Zhou, Zhilei Zhang, Zhe Su, Gaili Cao, Kun‐Wei Yeh, Ruipeng Li, Xianghui Xiao, Adam F. G. Leontowich, Yuan‐Yu Hsueh, Zhao Pan, Kam C. Tam, Badri Narayanan, Song Li, Yimin. A. Wu   +20 more
wiley   +1 more source

Intelligent Orthopedics: Machine Learning in Diagnosis of Bone Disease, Implants, and Bone Health Monitoring

Advanced Healthcare Materials, EarlyView.
Efficient recovery from traumatic or degenerative diseases is a great challenge, even after all the advancements in bone and cartilage regeneration. Machine learning (ML) algorithms have presented opportunities to enhance these aspects by accurately analyzing imaging data.
Maryam Kamaei, Hesam Mohammadi, Shamim Golafshan, Mojtaba Alehosseini, Mahsa Mohammadzadeh, Atefeh Golshirazi, Nasim Golafshan, Tatiane Eufrásio‐da‐Silva, Alireza Dolatshahi‐Pirouz, Gorka Orive   +9 more
wiley   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic‐Immunomodulatory Prevention of CIED Infection in Diabetes

Advanced Healthcare Materials, EarlyView.
Under NIR irradiation, PTCPP generates ROS to eliminate MRSA biofilms and promote M1 macrophage polarization for phagocytosis. After bacterial clearance, the material is phagocytosed by macrophages, shifting their polarization to M2 phenotype via metabolic reprogramming, which synergistically enhances anti‐infection therapy and wound healing.
Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng   +13 more
wiley   +1 more source

Comparative Histology of the Cornea and Palisades of Vogt in Various Non-Human Primates. [PDF]

Vet Sci
Klećkowska-Nawrot J, Chrószcz A, Aktaş A, Paszta W, Goździewska-Harłajczuk K, Poradowski D.   +5 more
europepmc   +1 more source

Engineering Concentration‐Dependent Intravitreal Mobility via Cyclic Arginine‐Enriched Nanocarrier Surface Modification: In Vivo Proof‐of‐Concept in a Porcine Large Animal Model

Advanced Healthcare Materials, EarlyView.
In this study, Hammer et al. highlight cyclic‐arginine surface engineering as a highly biocompatible, controllable, and concentration‐dependent regulator of intravitreal nanoparticle mobility in vivo in a translational large animal model. The cyclic arginine surface‐modification supports the development of next‐generation biomaterials for long‐acting ...
Maximilian Hammer, Bryan Calder Ackermann, Anna Stoß, Niklas Junker, Ludwig Geisweid, Sabrina Wohlfart, Jonathan Herth, Simon William Pohl, Manuel Ben Böhmann, André Schulz, Victor Aristide Augustin, Gerd Uwe Auffarth, Philipp Uhl   +12 more
wiley   +1 more source

Comparative literature in an age of Globalization: Une réponse

, 2011
Comparative literature in an age of Globalization: Une ...
DE HUENEN, ROLAND
core  

Illustrated catalogue of the Museum of Comparative Zo\uf6logy, at Harvard College / published by order of the Legislature of Massachusetts

no.4 ...
Harvard University. Museum of Comparative Zoology.
core   +1 more source