Results 71 to 80 of about 263,252 (335)

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao   +10 more
wiley   +1 more source

The lure of the foreign stage: Chronicles of Italian mobility to France in the long eighteenth century [version 1; peer review: 1 approved, 2 approved with reservations]

open access: yesOpen Research Europe
This article investigates the migration of three Italian-born artists working in France in the field of ephemeral entertainment and argues that their stories were part of a broader process of cultural history and artistic mobility of the long eighteenth ...
Elisa Cazzato
doaj   +1 more source

Photocatalytic Asymmetric C‐C Coupling for CO2 Reduction on Cu‐Zn Bimetallic Catalysts with Dipole‐Limiting Effects

open access: yesAdvanced Science, EarlyView.
Asymmetric Cu–Zn dual sites on EDTA‐grafted Ti‐MOF amplify the dipole‐limiting domain field (DLDF), facilitating C–C coupling. This strategy yields an exceptional C2H4 production rate of 308.72 µmol g−1 h−1 with 98.4% electron selectivity in photocatalytic CO2 reduction, highlighting the potential of asymmetric site engineering and local field ...
Peidong Ma   +8 more
wiley   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

open access: yesAdvanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling   +17 more
wiley   +1 more source

Political Discourse Approach Applied the Current Study Issue Occurred [PDF]

open access: yes, 2017
The research was to aim at approaching a political discourse as an effort to solve the issues. News reporting assigns meaning to issues by providing a continuous record of public events and visibility to the claims of actors.
Vurly, M. E. (Mike)   +1 more
core  

Attentional Bias to Facial Expressions of Different Emotions – A Cross-Cultural Comparison of ≠Akhoe Hai||om and German Children and Adolescents

open access: yesFrontiers in Psychology, 2020
The attentional bias to negative information enables humans to quickly identify and to respond appropriately to potentially threatening situations.
Cordelia Mühlenbeck   +5 more
doaj   +1 more source

The Role of Actual and Purported Origin in e‐Commerce Wine Pricing: Evidence From Italian and French Names on Labels

open access: yesAgribusiness, EarlyView.
ABSTRACT The origin of a product, if associated with good quality, can contribute to building a positive collective reputation, leading to a potential price premium. However, it is conceivable that a producer markets a product by evoking symbols, images, words, and values typical of places other than where it was designed or produced, creating a ...
Annalisa Caloffi   +2 more
wiley   +1 more source

Towards Universal Semantic Tagging [PDF]

open access: yes, 2017
The paper proposes the task of universal semantic tagging---tagging word tokens with language-neutral, semantically informative tags. We argue that the task, with its independent nature, contributes to better semantic analysis for wide-coverage ...
Abzianidze, Lasha, Bos, Johan
core   +1 more source

Three Reflections on Bilingualism [PDF]

open access: yes, 2014
Following a brief discussion on the understanding of the concept of bilingualism (and diglossia) the author shares with his audience the reflections on the role and significance of bi- and multilingualism in three areas: practical linguistic ...
Walczak, Bogdan
core   +2 more sources

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