Results 51 to 60 of about 856,790 (293)

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

open access: yesFEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang   +7 more
wiley   +1 more source

University Rating in the Global Educational Space

open access: yesВестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2020
Introduction. In assessing the quality of education, the author applies the rating approach. To date, a set of the most famous and authoritative ratings has been formed.
Ekaterina A. Antyukhova
doaj   +1 more source

Comment on 'What To Do (and Not To Do) with Times-Series-Cross-Section Data' [PDF]

open access: yes, 2006
Much as we would like to believe that the high citation count for this article is due to the brilliance and clarity of our argument, it is more likely that the count is due to our being in the right place (that is, the right part of the discipline) at
Beck, Nathaniel, Katz, Jonathan N.
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Rewards at the top: the European Union [PDF]

open access: yes, 2012
Book synopsis: Anyone observing the recent scandals in the United Kingdom could not fail to understand the political importance of the rewards of high public office.
Dimitrakopoulos, Dionyssis G.   +1 more
core  

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

How Populism and Polarization Affect Europe’s Liberal Democracies

open access: yesPolitics and Governance, 2020
In recent years, two phenomena have put Europe’s liberal democracies under strain: populism and polarization. The rise of populist parties, the increasing radicalization of publics and political discourse, as well as the expansion of hyperpartisan media ...
Heidi Schulze, Marlene Mauk, Jonas Linde
doaj   +1 more source

For What it’s Worth: The Political Construction of Quality in French and Italian Wine Markets

open access: yes, 2017
At the heart of political organization, we find weak and atomized individuals who aggregate their power to challenge concentrated power. Wine politics show us that within market economies we find the same political movements.
Carter, E.
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

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