Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
MARKET STRUCTURE IN BIOTECHNOLOGY: IMPLICATIONS FOR LONG-RUN COMPARATIVE ADVANTAGE [PDF]
A country specializing in a high technology industry may find that excess returns stemming from innovation are reallocated overseas as foreign-based multinationals access ongoing domestic R&D through alliances with or acquisition of established domestic ...
Lavoie, Brian F., Sheldon, Ian M.
core +1 more source
Comparative Analysis of the public discourse about fusion and nuclear energy before and after Fukushima: WP12-SER-ACIF-1 Final Report [PDF]
, 2013 This report presents a comparative analysis of media coverage of fusion and fission energy before and after the accident in the nuclear reactors of Fukushima, Japan.
Horta, Ana +3 more
core
Medical Therapy of Heart Failure with Reduced Ejection Fraction-A Call for Comparative Research. [PDF]
J Clin Med, 2021 Cotter G +6 more
europepmc +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
The Macro-Social Benefits of Education, Training and Skills in Comparative Perspective [Wider Benefits of Learning Research Report No. 9] [PDF]
, 2003 This report, the second from the Centre's strand of comparative research, complements an earlier WBL research report (Education, Equity and Social Cohesion: A Distributional Model) in exploring further themes of societal comparison and the distributional
Green, Andy, Preston, John
core +1 more source
Comparative research of intestinal microbiota diversity and body mass regulation in Eothenomys miletus from different areas of Hengduan mountain regions. [PDF]
Front Microbiol, 2022 Yan B, Jia T, Wang Z, Zhu W.
europepmc +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Comparative Research of Microstructure and Mechanical Properties of Stainless and Structural Steel Dissimilar Welds. [PDF]
Materials (Basel), 2021 Baskutis S +4 more
europepmc +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source