Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Comparative Research of Antioxidant, Antimicrobial, Antiprotozoal and Cytotoxic Activities of Edible <i>Suillus</i> sp. Fruiting Body Extracts. [PDF]
Judžentienė A, Šarlauskas J.
europepmc +1 more source
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
A Fresh Look at Oral Chemolysis for Non-Symptomatic Kidney Stones-Comparative Research of Potassium Citrate and Allopurinol Combination-Is Treatment Possible Without Stone Analysis? [PDF]
Coşkun A, Can U, Çanakçı C, Can M.
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Education, Globalisation and the role of Comparative Research [PDF]
Green, Andy
core +1 more source
The Macroeconomics of the Great Depression: A Comparative Approach [PDF]
Recently, research on the causes of the Great Depression has shifted from a heavy emphasis on events in the United States to a broader, more comparative approach that examines the interwar experiences of many countries simultaneously.
Ben S. Bernanke
core
Do Treatment Choices by Artificial Intelligence Correspond to Reality? Retrospective Comparative Research with Necrotizing Enterocolitis as a Use Case. [PDF]
Verhoeven R +3 more
europepmc +1 more source

