Results 81 to 90 of about 5,309,629 (283)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Comparative Regionalism - A New Research Agenda [PDF]

open access: yes
After the end of the Cold War, students of International Relations observed an expansion of inter-state activities at the regional level. Regional and sub-regional groupings appeared to gain momentum as the way in which countries cooperate and should ...
Tanja A. Börzel
core  

Leading Turnaround and Improvement in Low Performing Schools in Malaysia and Indonesia [PDF]

open access: yes, 2017
Improving the fortunes of low-performing schools, often in the most challenging circumstances, remains a persistent and pervasive challenge in many education systems (Meyers & Darwin, 2017).
Adams, Donnie   +4 more
core  

Media Use and Political Engagement: Cross-Cultural Approaches| Between Individual and Collective Social Effort: Vocabularies of Informed Citizenship in Different Information Environments

open access: yesInternational Journal of Communication, 2023
Information disorder and digital media affordances challenge informed citizenship as an ideal and in practice. While scholars have attempted to adapt the normative ideal to contemporary changes and challenges by introducing new metaphors and normative ...
Emilija Gagrčin, Pablo Porten-Cheé
doaj  

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

An Apparent Order of Sensory Ability Changes in Human Beings \ud [PDF]

open access: yes, 2009
Examination of records and personal documents of 1309 human beings isolated an apparent order of sensory ability changes, for 154 members of the sample both records and personal documents were available.
Lehmann, A.
core  

From National Borders to Digital Frontiers: Comparing the Impacts of Social Media Use on Transnational Identity Negotiation in South Korea and Taiwan

open access: yesJournal of East Asian Studies
Using data from the seventh wave of the World Values Survey, this study examines how social media use shapes the negotiation of transnational identity in South Korea and Taiwan—two countries characterized by distinct forms of nationalism—and whether ...
Shin Haeng Lee
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

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