Results 191 to 200 of about 5,398,298 (248)

Correction to: Comparison of two bundles for reducing surgical site infection in colorectal surgery: multicentre cohort study. [PDF]

BJS Open
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Upright and supine particle therapy of lung cancer: A 4D dosimetric comparison. [PDF]

Med Phys
Martire MC, Volz L, Durante M, Pankuch M, Graeff C.   +4 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Caudal Epidural Steroid Injection in adults with Chronic Lower Backache: Comparison of Landmark-Guided Technique and Ultrasonography-Guided Technique. [PDF]

J Orthop Case Rep
Raina S, Sharma P, Chauhan H, Ghani A, Singh M.   +4 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Effects of comprehensive nursing intervention on the postoperative gastrointestinal function and complications in patients undergoing endoscopic polypectomy. [PDF]

Am J Transl Res
Yu F, Peng X.
europepmc   +1 more source

The Impact of US Food and Drug Administration's Advisory and Enforcement Actions on US Sales of Esco Bars Products in 2023: Synthetic Control Approach.

JMIR Public Health Surveill
Shin H, Hannings J, Cahn Z, Xu X, Toblin R, Farrelly M, King BA.   +6 more
europepmc   +1 more source

Artificial intelligence in nongynecologic cytology: A systematic review of current research and commercial tools. [PDF]

Cancer Cytopathol
Byambadorj T, Alam MR, Chong Y.
europepmc   +1 more source