Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
A COMPARISON OF THE OPTICAL FORMS OF GLUTAMIC ACID FROM NORMAL AND CANCEROUS TISSUE
J. M. Johnson
openalex +1 more source
A Comparison of Parenterally and Orally Supplied Protein Hydrolysate for Utilization of the Nitrogen in Long Continued Feeding Experiments [PDF]
Carl Alper, Bacon F. Chow, S DeBIASE
openalex +1 more source
Research on conveyor belt damage detection method based on FDEP-YOLOv8. [PDF]
Yuan Y +5 more
europepmc +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
A COMPARISON OF THE WASSERMANN AND LUETIN REACTIONS IN 744 INDIVIDUALS [PDF]
Edward B. Vedder
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Hybrid Young's double-slit experiment and differential evolution for enhanced photovoltaic parameter estimation. [PDF]
Alqadi BS +9 more
europepmc +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
COMPARISONS OF THE OXIDATION OF C19-HYDROXYSTEROIDS BY GUINEA PIG LIVER HOMOGENATES
Charles D. Kochakian +2 more
openalex +1 more source

