Results 151 to 160 of about 2,597,630 (341)

The Pivotal Role of GR‐CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun, Jie Liu, E Xiang, Xia Li, Xuerong Yan, Yuxi Wang, Feng Li, Hao Kou, Hui Wang, Yu Guo   +9 more
wiley   +1 more source

Inhibition of Calcium‐Dependent Lipid Droplets Relocation of ACSL4‐PKCβ‐ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis

Advanced Science, EarlyView.
This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou, Jing Luan, Xiaoyong Xu, Jianhua Qin, Shuang Ma, Jiyuan He, Na Sun, Wei Zhang, Minghui Gao   +8 more
wiley   +1 more source

Gluteal compartment syndrome secondary to superior gluteal artery injury following pelvis fracture: A case report and review of literature

, 2016
Murat Songür, Ercan Şahin, Sinan Zehir, İbrahim İlker Öz, Mahmut Kalem   +4 more
openalex   +1 more source

Hand compartment syndrome due to extravasation of contrast medium. A technical error. A report of a case and review of the literature [PDF]

, 2022
Nikolaos Papatheodorou, Anthimos Keskinis, Paraskevas Georgoulas, Konstantinos Tilkeridis, Sotirios Botaitis, Sempachedin Perente, Ioanna Kougioumtzi   +6 more
openalex   +1 more source

Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion

Advanced Science, EarlyView.
FUT8‐mediated core fucosylation of CD47 at N111 blocks SMURF1 binding and reduces CD47 ubiquitination and degradation. Blocking N111 glycosylation reduces CD47 expression and promotes macrophage phagocytosis of tumor cells. Furthermore, ablating CD47 core fucosylation boosts CD103+ dendritic cells (DCs) infiltration, increases natural killer (NK) cell ...
Yuting Cao, Siyuan Chai, Mingyang Li, Xiaoming Chen, Jiating Hu, Bingyi Lin, Liming Wu, Wen Yi, Qiang Zhu   +8 more
wiley   +1 more source

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

Advanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen, Yahui Gao, Yulin Wang, Ting Lei, Zheng Qu, Yuhan An, Jiaxu Fu, Xin Li, Fangjun Liu, Yan Li   +9 more
wiley   +1 more source

Ophidian Venom and Occlusive Vascular Event: A Case Report

Medical Journal of Dr. D.Y. Patil Vidyapeeth
Most Indian hospitals, especially in rural and semi-urban areas, are regularly faced with the necessity of admitting and treating victims of snakebite.
Mahesh Mahadevaiah, Drishya Appachu, Madhumitha Mahesh   +2 more
doaj   +1 more source

Acute Compartment Syndrome Post‐Thrombolysis for Acute Pulmonary Embolism—A Case Report [PDF]

Andrew Mpagwuni Ziblim, Mawunyo Ntumi, Nana Kwame Baah‐Adade, Samuel Ofosu Agamah, Dziwornu Kunutsor, E. Acheampong, Abdul‐Wakil Wunpini Salifu, Augustine Frimpong Marfoh, Nyagse Salifu, Ernest Ofosu‐Appiah   +9 more
openalex   +1 more source

Rhabdomyolysis and Peripheral Neuropathy Without Compartment Syndrome, Induced by Antipsychotic Drug Intoxication: A Case Report [PDF]

, 2023
Ho Sig Jang, Kook Jong Kim, Hyun Ho Kong, Yeongtae Park   +3 more
openalex   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source