Results 131 to 140 of about 89,195 (253)

Human Tendon‐on‐Chip: Unveiling the Effect of Core Compartment‐T Cell Spatiotemporal Crosstalk at the Onset of Tendon Inflammation

Advanced Science
The lack of representative in vitro models recapitulating human tendon (patho)physiology is among the major factors hindering consistent progress in the knowledge‐based development of adequate therapies for tendinopathy.Here, an organotypic 3D tendon‐on ...
Syeda M. Bakht, Alberto Pardo, Manuel Gomez‐Florit, David Caballero, Subhas C. Kundu, Rui L. Reis, Rui M. A. Domingues, Manuela E. Gomes   +7 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

The fate of insulin bound to adipocytes. Evidence for compartmentalization and processing.

, 1978
C. Ronald Kahn, Kathleen L. Baird
openalex   +1 more source

Hotspot Zuidplaspolder: Climate adaptation in the Zuidplaspolder [PDF]

Building at the lowest point in the Netherlands, in the Zuidplaspolder, is viewed as a challenge and not something that is impossible. The Xplorelab approach in the Hotspot Zuidplaspolder project is a combination of research, implementation of ideas into
Goosen, H., Mes, R., Peen, M., Pelt, F., van, Smeets, L., Steekelenburg, M.G.N., van   +5 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Cerebrospinal Fluid HIV-1 Compartmentalization in a Patient With AIDS and Acute Varicella-Zoster Virus Meningomyeloradiculitis [PDF]

, 2013
E. Falcone, Ademiposi A. Adegbulugbe, Virginia Sheikh, Hiromi Imamichi, Robin Dewar, Dima A. Hammoud, Irini Sereti, H. Clifford Lane   +7 more
openalex   +1 more source

Microfluidic Production of Spatially Structured Biomimetic Microgels as Compartmentalized Artificial Cells

Small Science
Artificial cells serve as promising micro‐robotic platforms that replicate cellular features. One ubiquitous characteristic of living cells is compartmentalization of content in distinct and well‐defined locations.
Matthew E. Allen, James W. Hindley, Robert V. Law, Oscar Ces, Yuval Elani   +4 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Preparing For the Crossfire: Equipping Evangelical Leaders for Service in Public Schools

, 2013
This article addresses the preparation and support needed by evangelicals who serve as administrators and teacher leaders in public school settings. Educational leadership is lonely, demanding, and draining.
Sehorn, Gary F., Dr.
core