Results 81 to 90 of about 87,932 (314)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
On the compatibility condition for linear systems and a factorization formula for wave functions
, 2012 The well-known compatibility condition for linear systems wx=Gw and wt=Fw is considered and new results are obtained. In this way, a factorization formula for wave functions, which is basic in the inverse spectral transform approach to initial–boundary ...
Alexander Sakhnovich +1 more
core +1 more source
O dwu odmianach metody Pohlhausena i ich zastosowaniu do przepływu w sąsiedztwie punktu spiętrzenia
Engineering Transactions, 1968 This paper contains a description of two variants of the Pohlhausen's method and their application to the stagnation flow point at a moving wall. The two variants differ by the «compatibility» condition which is a conclusion from the boundary layer ...
W.J. Prosnak, M.E. Klonowska
doaj
Physical Education of Students, 2013 The degree of trained and predisposition of work is certain from data of mechanisms of energy-supply of sportswomen. 40 students took part in research. The degree of trained sportswomen was determined on results a vectorcardiography.
O.S. Kozhanova
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Bandlimited Distortionless Material Design by an Approximation of the Heaviside Condition
, 2020 The distortionless propagation of signals in a medium offers a way to preserve the signal integrity. There exists a condition for distortionless propagation on a transmission line known as the Heaviside condition.
De Lauretis, Maria, +3 more
core +1 more source
John Martin Fisher’s Viewpoint Regarding the Necessary Free Will in Moral Responsibility [PDF]
حکمت و فلسفه, 2014 Free will, as the most pivotal human feature, on the one hand, has been considered, in the West, as the most fundamental condition of moral responsibility, and, on the other, based on the world being deterministic, has opposed determinism.
zahra khazaei, fatemeh tamadon
doaj
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Dynamic Compatibility Control Method Research for AC-DC Locomotive under Low-voltage Condition
机车电传动, 2013 With traffic increasing, voltage of some electrified railway’s power-supply network was continuously reducing, which influenced locomotive normal operation.
LUO Ji-guang, QIAO Xian-hua
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source