Results 91 to 100 of about 15,739,042 (307)

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Differentiation as a Consequence of Choice and Decentralization Reforms—Conditions for Teachers’ Competence Development

, 2017
This paper examines the conditions for teacher competence development as they relate to the current restructured governance of the education sector in Sweden.
Karolina Parding, A. Berg-Jansson, Therese Sehlstedt, S. McGrath-Champ, Scott Fitzgerald   +4 more
semanticscholar   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Twenty Years of Basic Vocational Education Provision in Spain: Changes and Trends

International Journal for Research in Vocational Education and Training, 2015
Our contribution attempts to review basic vocational education programmes in Spain over the past 25 years. We intend to compare the evolution of these programmes in terms of conception and conditions of delivery in order to find out how different they ...
Fernando Marhuenda, Francesca Salvà, Almudena A. Navas Saurin, Miriam Abiétar López   +3 more
doaj   +1 more source

Redefining action competence: The case of sustainable development

, 2020
The concept of Action Competence (AC) has been interpreted in different ways in various domains of the educational sciences. Given the rising scholarly attention to AC, these diverse interpretations are problematic because they hinder a common ...
W. Sass, J. Boeve-de Pauw, Daniel Olsson, N. Gericke, S. de Maeyer, P. van Petegem   +5 more
semanticscholar   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

FlightScope: An Experimental Comparative Review of Aircraft Detection Algorithms in Satellite Imagery

Remote Sensing
Object detection in remotely sensed satellite pictures is fundamental in many fields such as biophysical and environmental monitoring. While deep learning algorithms are constantly evolving, they have been mostly implemented and tested on popular ground ...
Safouane El Ghazouali, Arnaud Gucciardi, Francesca Venturini, Nicola Venturi, Michael Rueegsegger, Umberto Michelucci   +5 more
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Temporal Regulation of the Transformasome and Competence Development in Streptococcus suis

Frontiers in Microbiology, 2016
In S. suis the ComX-inducing peptide (XIP) pheromone regulates ComR-dependent transcriptional activation of comX (or sigX) the regulator of the late competence regulon. The aims of this study were to identify the ComR-regulated genes and in S. suis using
E. Zaccaria, M. Wels, P. van Baarlen, J. Wells   +3 more
semanticscholar   +1 more source