Advanced Science, EarlyView.Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian +5 more
wiley +1 more source
Identifying Core Competencies for Prefieldwork Occupational Therapy Students in Adult Therapy: A Delphi Study With Clinical Therapists. [PDF]
Occup Ther IntFan SC, Shao JY, Lu TY, Chi WC, Hung CH.
europepmc +1 more source
Advanced Science, EarlyView.Schematic illustration of the proposed model. Primary CAFs are isolated from fresh human GBM specimens according to established protocols. GLUL is essential for pro‐angiogenic capacity of CAFs through its impact on the PI3K/AKT pathway. GLUL enhances the pro‐angiogenic capacity of CAFs, driving aberrant tumor vasculature that fuels tumor growth ...
Qing Zhang +4 more
wiley +1 more source
A rank ordering and analysis of nine resilience competencies demonstrates the special importance of thought management in maintaining resilience. [PDF]
Sci RepEpstein R, Godoy S, Wang N, Newland A.
europepmc +1 more source
Advanced Science, EarlyView.This study presents a 3D lymphoid tissue model engineered from adipose‐derived stem cells differentiated into fibroblastic reticular cell–like networks and co‐cultured with immune cells. The engineered system successfully generates antigen‐specific antibodies and cytokine responses, providing a platform for studying adaptive immunity, vaccine efficacy,
Mei ElGindi, Shaza Karaman, Jeremy Teo
wiley +1 more source
Educators' perspectives for modernizing dental teaching competencies at Prince Sattam Bin Abdulaziz University-Saudi Arabia: a needs assessment study. [PDF]
Front Med (Lausanne)Robaian A +5 more
europepmc +1 more source
NUSAP1 Recruits DAXX to Suppress HIF‐Driven Triple‐Negative Breast Cancer Progression
Advanced Science, EarlyView.A double‐negative feedback loop is identified in TNBC where NUSAP1 bridges HIF and DAXX via its microtubule‐associated domain (MAD) to recruit SETDB1, repressing HIF transcriptional activity by depositing the H3K9me3 repressive mark on HIF target genes, while HIF itself suppresses NUSAP1.
Yating Du +14 more
wiley +1 more source
Core shared competencies between physicians and nurses in primary care: a Delphi study in Korea. [PDF]
Korean J Med EducLee JY, Min YH, Yim J, Park KH, Yune SJ.
europepmc +1 more source
Advanced Science, EarlyView.CRISPR‐FLEXMO (CRISPR with flexible PAM in MOF encapsulation) integrates a PAM‐relaxed Cas12a K607R enzyme with a manganese‐coordinated MOF for broad‐spectrum diagnosis of bacterial sepsis. The MOF enhances activity and preserves functionality under heat, solvent, and chaotropic stress, supporting long‐term room‐temperature storage.
Tathagata Pal +3 more
wiley +1 more source
Competency-based spiritual care education program for undergraduate nursing students: a quasi-experimental study. [PDF]
BMC NursSitefane S +5 more
europepmc +1 more source