Results 121 to 130 of about 142,318 (259)

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Is the Theory of Competences Competent?

Управленческое консультирование, 2018
Today the theory of competences is extensively introduced into the practice of teaching, training and certification of qualified personnel . Many issues are published nowadays to provide well-grounded reasons of the validity and effectiveness of this theory application.
openaire   +1 more source

The International Sports Physiotherapy Competencies and Standards 2025: The SportsComp Project on Higher Education to Improve Competency in Sports Physiotherapy. [PDF]

Int J Sports Phys Ther
Constantinou M, Ramponi C, Tassignon B, Dick E, Lathouwers E, Arend M, Lepasalu L, Hirvonen A, Sihvonen S, Paasu-Hynynen S, Kapreli E, Tsokani A, Strimpakos N, De Michelis Mendonça L, Verschueren J.   +14 more
europepmc   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Closing the knowledge-practice gap in veterinary antimicrobial stewardship: why competency-based continuing professional development is needed in veterinary systems. [PDF]

Front Vet Sci
Bwalya EC, Chileshe C, Mwenda R, Phiri B, Chibango K, Chishimba V, Chawinga K, Sinyawa T, Sianzinda E, Goma F, Mudenda NB, Mumba C.   +11 more
europepmc   +1 more source

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Constructing A Core Competency Evaluation Index System for Incontinence Specialist Nurses: A Delphi Study. [PDF]

Nurs Open
Tian XM, Chen YZ, Xie SM, Shao HM, Li YY, Liu J.   +5 more
europepmc   +1 more source

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

From Personal Readiness to Systems Change: Progressive Clinician Cross-Competency Development in the Robert Wood Johnson Foundation Clinical Scholars Program. [PDF]

J Healthc Leadersh
Caton L, Rohin W, Adatsi G, Berthiaume R, Corbie G, Fernandez CSP.   +5 more
europepmc   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source