Results 21 to 30 of about 288,454 (277)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Competing Discourses of Gender and Power Relations: Complexities and Ambiguities in the Algerian Architecture Classroom

open access: yesAltralang Journal
The objective of this investigation is to unveil male dominance assumptions and discourses of gender differentiations in the architecture classroom, in light of the possibilities for resistance and reinterpretation of the social practices.
Amina BABOU
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Immaginare è simulare: cosa e come?

open access: yesRivista di Estetica, 2013
Imagination is analysed by contemporary philosophers of mind in order to discover its features and its place in our cognitive architecture. More precisely, the debate has given birth to two competing approaches: simulationism and single-code theory ...
Margherita Arcangeli
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Dual-Branch Multi-Dimensional Attention Mechanism for Joint Facial Expression Detection and Classification

open access: yesSensors
This paper addresses the central issue arising from the (SDAC) of facial expressions, namely, to balance the competing demands of good global features for detection, and fine features for good facial expression classifications by replacing the feature ...
Cheng Peng   +5 more
doaj   +1 more source

Fake face detection based on a multi discriminator deep CNN architecture (MDD-CNN)

open access: yesActa Polytechnica, 2023
Due to the robustness of the deep learning tools used to design these applications, fakes are becoming increasingly common as these applications become more widely available and accessible to the general public.
Chemesse Ennehar Bencheriet   +4 more
doaj   +1 more source

Creating a Strategic IT Architecture Competency: Learning in Stages [PDF]

open access: yesSSRN Electronic Journal, 2003
IT architecture is often assumed to follow business strategy, to align IT with the business's strategic objectives. Increasingly, though, many business strategies depend on specific underlying IT capabilities. To develop a synergy between business strategy and IT architecture, firms must develop organizational competencies in IT architecture.
openaire   +3 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

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