Results 51 to 60 of about 288,454 (277)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Autorialità contro autenticità: la contesa internazionale per la leadership metodologica sul ‘restauro del moderno’ /

open access: yesRestauro Archeologico
This paper examines the conflicting viewpoints on the conservation of Modern Heritage that emerged in the late 1980s and continue to evolve today. Through a critical analysis of cultural positions and conservation guidelines from Italy, the United ...
Davide Galleri
doaj   +1 more source

Analysis and Modeling Time Series of Water Flow into Mosul City A Comparative Study [PDF]

open access: yesالمجلة العراقية للعلوم الاحصائية, 2010
This paper presents fits for neural network model , and comparative resulting forecasts with those obtained from Box-Jenkins Method. We use time series data of Tigris's monthly flow into Mosul city from 1950-1995. To perform a comparative .
doaj   +1 more source

Competence Model for the Architectural Engineering Professional

open access: yesProcedia Engineering, 2013
AbstractMotivation. Modern design practice, where an architect works with engineers in a large team, lacks optimization. If collaboration between the professions of architecture (A.) and engineering (E.) were improved, it would result in more efficient structures.
Parasonis, Josifas, Jodko, Andrej
openaire   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Multi-objective optimization for dynamic logistics scheduling based on hierarchical deep reinforcement learning

open access: yesScientific Reports
This paper proposes a novel hierarchical deep reinforcement learning framework for multi-objective optimization of dynamic logistics scheduling problems.
Jiantao Su, Saohua Dong
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Low-Complexity Architecture for High-Speed 50G-PON LDPC Decoder

open access: yesIEEE Access
We propose a hardware architecture for 50G-PON LDPC decoder achieving high throughput and high error correcting capability while maintaining low level of resource utilization and implementation complexity.
Kon-Woo Kwon   +4 more
doaj   +1 more source

Image Forgery Detection and Localization via a Reliability Fusion Map

open access: yesSensors, 2020
Moving away from hand-crafted feature extraction, the use of data-driven convolution neural network (CNN)-based algorithms facilitates the realization of end-to-end automated forgery detection in multimedia forensics.
Hongwei Yao   +4 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

open access: yesAging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang   +3 more
wiley   +1 more source

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