Results 71 to 80 of about 78,948 (266)

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

Unreliability of markets – collusion of players. Detection methods in the light of the competition policy

Ekonomia i Prawo, 2009
This paper presents a review of a methodology of detection of overt or tacit collusion in the light of the modern competition policy based on the game theory.
Sylwester Bejger
doaj   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

Competition Policy: Administrative-Territorial Aspect

Управленческое консультирование, 2018
In this article the analysis of validity and expediency of improvement of the mechanism of realization of a competition policy on more isolated territorial units, such as is offered: territorial subject of the Russian Federation, municipal territorial ...
Artem Vladimirovich Polenov
doaj  

South African competition policy on excessive pricing and its relation to price gouging during the COVID-19 disaster period. [PDF]

S Afr J Econ, 2021
Boshoff WH.
europepmc   +1 more source

Large Language Model‐Informed Dual‐Track AI Framework for the Synergistic Design of Crack‐Free and High‐Strength Superalloys

Advanced Science, EarlyView.
This paper illustrates a knowledge‐augmented dual‐track AI framework for advanced superalloy design. First, Large Language Models translate metallurgical heuristics into explicit rules to rapidly prune a vast compositional search space. Subsequently, LLM‐distilled priors safely guide a reinforcement learning agent during autonomous process optimization,
Jian Yao, Junkang Wu, Jie Su, Fuzhu Wang, Zi Wang, Li Wang, Liming Tan, Lan Huang, Feng Liu, Yong Liu   +9 more
wiley   +1 more source

Slovenian and German Competition Policy Regimes: A comparative analysis

Naše Gospodarstvo, 2017
We use an institutional approach to analyze differences and similarities between competition policy regimes in Slovenia and Germany. We first indicate differences that exist in the implementation of EU competition law at the national level, given the ...
Polk Andreas, Primec Andreja
doaj   +1 more source

Hochschulpolitik als Komplement von Wettbewerbspolitik. Education Policy as a Complement Competition Policy

Eesti Majanduspoliitilised Väitlused, 2014
The current economic development in europe is a continuous cause for concern. First and foremoust in terms of the dept crisis, having a closer view regarding disbalances of competitiveness.
Jörg Dötsch
doaj   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Economic Principles of Predatory (Exclusionary) Pricing in the US and in the EU their (mis)Application in Some Recent Competition Law Cases of the European Community Commission and the Court of First Instance

Competitio, 2009
Predatory pricing is one of the most debated issue among the many possibly abusive behaviors of a dominant firm. The general prohibition of the abuse of a dominant power in the competition law is meant to render more difficult to use that power but not ...
Zoltán Bara
doaj   +1 more source