Results 91 to 100 of about 5,470,399 (296)
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
MIXED BUNDLING STRATEGIES AND MULTIPRODUCT PRICE COMPETITION [PDF]
This paper deals with price competition among multiproduct firms. We consider a model with n firms and one representative buyer. Each firm produces a set of products that can be different or identical to the other firms' products.
Ivan Arribas, Amparo Urbano
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Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Dominance-discovery and discovery-exploitation trade-offs promote diversity in ant communities.
PLoS ONE, 2018 In ant communities, species coexist by using different foraging strategies. We developed an adaptive dynamics model to gain a better understanding of the factors that promote the emergence and maintenance of strategy diversity.
Louise van Oudenhove +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
A study of triathletes’ race strategies in different competition environments
HeliyonWhat is known, sports performance is impacted by a variety of factors. While most people understand the importance of training, proper nutrition, and adequate rest, not as many recognize the impact of environmental factors on athletic performance.
Junhui Zhao, Yan Wu, Jiangqian Zhang
doaj +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Revista Gestão Universitária na América Latina, 2012 The competition from consolidators in the educational market has intensified in the national and regional markets, such as Santa Catarina State, pressing the small and medium size IES to establish strategies of competition, cooperation and coopetition ...
Jorge Gaio +2 more
doaj
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
The role of sales effort on manufacturer's channel strategies
MATEC Web of Conferences, 2018 Competing manufacturers, who sell their products through retailers, may face the strategic distribution channel design question of whether to establish an “store-within-store” channel or not.
Li Baixun, Chen Guo, Nan Yaru
doaj +1 more source