Results 51 to 60 of about 375,089 (245)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Models of Innovation Activity Firms and the Competitive State [PDF]
Журнал институциональных исследований, 2015 The paper clarified the concept of innovation activity of firms from the perspective of the model open innovation with traditional and alternative approaches to the methods of the protection of innovation activity results outlined.
Nekrasova Ekaterina, A. +1 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
TECHNICAL TRAINING OF WOMEN’S FOOTBALL PLAYERS
Вестник Кемеровского государственного университета, 2014 The paper focuses on technical training of women’s football players. The data of pedagogical observations over competitive activity during the official matches of the Russian championship among women’s teams are provided. The quantitative and qualitative
N. V. Trusova +3 more
doaj
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
ESTIMATION OF COMPETITIVE ACTIVITY IN SYNCHRONIZED SWIMMING
Physical Education of Students, 2013 Aim – is to develop the approach to technical complexity estimation of free routine composition in synchronized swimming. Were analyzed and considered free routine compositions of the strongest swimmers in European and World Championships during the ...
L.M. Shul'ga, T.I. Rudkovskaya
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Repeated Acceleration Activity in Competitive Youth Soccer
Central European Journal of Sport Sciences and Medicine, 2016 Soccer match-play is increasingly characterised by short, high-speed bursts reliant on the ability to accelerate. Performance is impaired after peak acceleration activity and during the second half and may compromise a player’s effectiveness.
Steve Atkins +3 more
doaj +1 more source