Results 81 to 90 of about 375,089 (245)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The influence of cognitive functions on competitive performance indicators in wrestlers of different qualification levels

Слобожанський науково-спортивний вісник
Background and Study Aim. Modern Greco-Roman wrestling is characterized by increasing demands on all aspects of athletes’ preparedness, including not only physical, functional, and technical-tactical characteristics, but also the level of development of ...
Yrui Tropin, Vyacheslav Romanenko, Volodymyr Shatskykh, Nataliia Sereda, Volodymyr Mikhalskyi, Valerii Dzherelii   +5 more
doaj   +1 more source

Competition performance of rugby-players of youth championship of Europe U-20. [PDF]

Pedagogìka, Psihologìâ ta Mediko-bìologìčnì Problemi Fìzičnogo Vihovannâ ì Sportu, 2012
The results of pedagogical supervision and comparative analysis of components of contention activity of the best commands of participants of zonal and final part of championship of Europe are rotined on rugby among masculine youth collapsible commands ...
Kvasnitsa O.M., Bazyl'chuk O.V.
doaj  

Is Self-Sacrificial Competitive Altruism Primarily a Male Activity?

Evolutionary Psychology, 2012
This study explored the basis of self-sacrificial prosocial behavior in small groups. Seventy-eight undergraduates (39M, 39F) filled out a thirty-item personality scale and then participated in a “group problem-solving study” in which the monetary ...
Francis T. McAndrew, Carin Perilloux
doaj   +1 more source

The Role of Psychological Qualities in the Process of the Formation of Sports Skill of Young Basketball Players

Фізичне виховання, спорт і культура здоров’я у сучасному суспільстві, 2018
Purpose: to determine the level of the development of indices of the influence of the important psychological qualities and the personality characteristics that defines the effectiveness of the competitive activity of young basketball players in the ...
Anatoly Rovniy, Vladlena Pasko
doaj   +1 more source

The impact of competitive and non-competitive activities on children's aggression

فصلنامه علمی- پژوهشی اصول بهداشت روانی, 2019
Introduction: Regarding to the importance of children and adolescents' aggression in the prediction of problems over the psycho-social adjustments in future, the current study was conducted in order to compare the impact of competitive and non-competitive activities on the aggression of children aged 7-9 and 10-12.
Ja'far Sedaghati, Abdollah Ghassemi, Ma'ssomeh Shojaei   +2 more
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Leveraging activity-based costing and information technology strategic enhancements in decision-making, and competitive advantage in industrial projects [PDF]

Journal of Project Management
This study examined the impact of activity-based Costing ABC and information technology IT on decision-making and competitive advantage in Sudanese industrial projects.
Altahir Saad Ahmed Saad, Abubkr Abdelraheem, Nasrin Babiker Mohamed Elbashir   +2 more
doaj   +1 more source

Competition And Real Activities Manipulation

Journal of Applied Business Research (JABR), 2019
We enrich the research on income manipulation by establishing a link among companies’ price-setting control and the extent of real activities management. Examining three types of real activities management, the results reveal an interesting asymmetry in how companies employ income manipulation based on their pricing strength. We discover that companies
Sudip Datta, Mai Datta, Vivek Singh
openaire   +2 more sources