Results 31 to 40 of about 172,874 (247)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

STUDI KESIAPAN DAN KESADARAN ORGANISASI UNTUK MENGHADAPI KEUNGGULAN SEMENTARA DALAM PERSAINGAN BISNIS PADA UNIT BISNIS INNOVATION AND DESIGN CENTER (IDeC) PT TELKOM INDONESIA TBK

Jurnal Manajemen Indonesia, 2017
Dinamika lingkungan bisnis saat ini telah menyulitkan perusahaan untuk memperoleh keunggulan yang berkelanjutan. Prilaku pesaing semakin sulit diprediksi sehingga strategi bersaing perusahaan sering kali tidak cukup kuat untuk mempertahankan daya ...
Yudi Pramudiana, Risris Rismayani, Yunus Thariq Rizky   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

BUSINESS COMPETITORS AND COMPETITIVE ADVANTAGE [PDF]

Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2013
The paper presents the concept of competition, both from the perspective of the economic sector –where it is characteristic for pure monopole, oligopoly, monopole competition and pure competition, as well asfrom the market’s point of view – where it ...
SUCIU TITUS
doaj  

COMPETITIVE PRODUCT ADVANTAGES

Annals of Dunarea de Jos University. Fascicle I : Economics and Applied Informatics, 2006
Cost advantages may be either internal or external. Internal economics of scope, scale, or experience, and external economies of focus or logistical integration, enable a company to produce some products at a lower cost than the competition. The coordination of pricing with suppliers, although not actually economizing resources, can improve the ...
Angela Eliza Micu, Adrian Micu
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

PERUMUSAN STRATEGI PERUSAHAAN BERDASARKAN COMPETITIVE ADVANTAGE

Jurnal Ilmiah Teknik Industri, 2012
Perusahaan Tenun Ikat Lestari Indah adalah perusahaan pembuatan kain dengan alat tenun bukan mesin. Dalam menjalankan bisnisnya, perusahaan menghadapi berbagai kendala, diantaranya daya beli masyarakat menurun akibat situasi perekonomian yang tidak ...
Endah Utami, Ali Imron
doaj   +3 more sources

Managerial conceptualisation of Competitive advantage

Entrepreneurship and Sustainability Issues
This paper aimed to fill the gap in the managerial conception of competitive advantage by identifying and describing the specific sources that enable the firm to achieve higher economic value.
Horymír Kalmus, Marek Vochozka, Jarmila Straková   +2 more
doaj   +1 more source

Corporate reputation and competitive advantage [PDF]

Marketing (Beograd. 1991), 2009
As the international environment changes, a closer inspection of the competitiveness drivers that change along with it becomes necessary. The rules are changing - competition is getting tougher, stakeholders are multiplying and the role of companies as ...
Mitić Sanja
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