Results 71 to 80 of about 23,348,161 (293)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Analysis and comparison of competitive balance in the Spanish ACB basketball league : a preliminary study [PDF]
, 2009 Regardless its relevance in sports economics, competitive balance has not been studied neither in Spanish nor in European professional basketball. In this preliminary study we measured the competitive balance in the Spanish ACB League from seasons 1983 ...
Pino-Ortega, José +4 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
COMPETITIVE ANALYSIS OF U.S. FOOD PROCESSING PLANTS [PDF]
This paper presents a model-based approach for competitive analysis of manufacturing plants in the U. S. food processing industry. As part of this approach, plant competitiveness is measured using Operational Competitiveness Ratings Analysis (OCRA) -- a ...
Kocha, Bart +2 more
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Innovation, Imitation and Competitive Value Analysis
Symphonya, 2012 The most widespread kind of innovation in global markets is incremental innovation, which modifies business processes, typically without visible manifestations outside the company.
Margherita Corniani
doaj +3 more sources
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Competitive scenarios increase competition in women: A meta-analysis.
Evolutionary Behavioral Sciences, 2021 Until recently, few researchers have closely investigated women’s intrasexual competition. A meta-analysis of 14 published studies with 61 effect sizes (N = 2,100) assessed the size of the effect of women’s competition. I hypothesized that 1) exposure to competitive situations would cause women to behave more competitively than women not exposed to ...
openaire +1 more source
Competitive Analysis of the Online Leasing Problem for Scarce Resources. [PDF]
Int J Environ Res Public Health, 2023 Lu J, Chen N, Feng X.
europepmc +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source