Results 51 to 60 of about 1,725,032 (267)

Intranasal Delivery of Gallium–Quercetin Nanoparticles for Multi‐Target Ferroptosis Inhibition in Parkinson's Disease

Advanced Science, EarlyView.
Leveraging the chemical similarity between Ga3+ and Fe3+ as well as the antioxidant properties of quercetin, gallium–quercetin nanoparticles (GQNPs) were prepared to integrate iron homeostasis regulation, oxidative stress suppression, and mitochondrial protection for multi‐target ferroptosis inhibition in Parkinson's Disease.
Keyang Xu, Dandan Kou, Xiao Xiao, Bingbing Bai, Caide Liu, Mengyao Wu, Yadan Shi, Mengdan Xu, Xiaoyi Cao, Haodi Qi, Shuhua Wu, Jianfeng Zeng, Mingyuan Gao   +12 more
wiley   +1 more source

Analysis of the competitive cognitive trait anxiety of aerobics athletes and research on the intervention of virtual reality technology [PDF]

SHS Web of Conferences
This study aims to explore the relationship between Organizational Stressors for Sport Performers, Sports Mental Toughness and aerobics athletes’ Competitive Cognitive Trait Anxiety, and to analyze the role of virtual reality technology in the regulation
Zhang Yu, Pang Lan
doaj   +1 more source

Competitive Anxiety in Lifesavers and Swimmers

International Journal of Aquatic Research and Education, 2007
This study examined state and trait anxiety in competitive lifesavers and swimmers. The participants completed the SAS and the CSAI-2d before a training session and the CSAI-2d again before a competition. The competitive lifesavers were found to have lower levels of cognitive and somatic anxiety than competitive swimmers. Both groups were found to have
Avramidou, Eleftheria, Avramidis, Stathis, Polman, Remco   +2 more
openaire   +3 more sources

The prevalence of dental anxiety across previous distressing experiences [PDF]

, 2010
Aims: To compare the prevalence of high dental anxiety across a variety of past distressing experiences with a previously reported Dutch sample. Method: University students from the UK (N=1024) completed an online survey containing; the Modified Dental ...
Humphris, Gerald Michael, G. Humphris, King, Kristel, K. King   +3 more
core   +1 more source

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

Advanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo, Ke Fang, Changjiang Zhao, Jiachao Xiong, Yuan Zhu, Mingyang Lu, He Yan, Zihan Li, Baojin Wu, Hua Jiang, Yufei Li   +10 more
wiley   +1 more source

Analysis of competitive anxiety levels among the age group 4–5 swimming athletes

Sriwijaya Journal of Sport
Research Problems: Anxiety is one of the psychological factors that can affect athletes' performance during competition. Young athletes are more susceptible to competitive anxiety due to limited competitive experience, underdeveloped emotional regulation,
Pandu Kurnia Sujiwo, Shinta Masitho Windriyani, Anangga Widya Pradipta, Rubbi Kurniawan   +3 more
doaj   +1 more source

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

Does competitive anxiety mediate the relationship between motor abilities and entrance exam performance?

Kinesiologia Slovenica
Achieving competitive success in sports often requires navigating high-stress, anxiety-inducing situations. While motor abilities are fundamental for athletic performance, psychological factors such as anxiety also significantly impact competitive ...
Srboljub Žunić, Ana Orlić, Ana Vesković, Aleksandar Nedeljković, Saša Đurić   +4 more
doaj   +1 more source

Near‐Infrared Fluorescent PROTAC Enables Theranostic Imaging and Selective Tau Degradation in Alzheimer's Disease

Advanced Science, EarlyView.
Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren, Qian Yue, Ning Gao, Qiu‐Lian Hao, Yan Huo, Chuchu Li, Xinyue Leng, Lu‐Lu Sun, Maggie Pui Man Hoi, Hai‐Hao Han, Mingliang Ma, Xu‐Wen Li   +11 more
wiley   +1 more source

Beyond Probiotics: Postbiotics for Healthy Aquaculture

Advanced Science, EarlyView.
This critical review assesses limitations of probiotics and proposes postbiotics, preparations of inanimate microorganisms and their metabolites, as a more stable, controlled, and biosafe formulation. Postbiotics offer significant advantages during industrial aquafeed production and storage. However, their practical implementation is currently hindered
Michael Leonidas Chikindas, Delin Xu, Igor V. Popov, Kayque Ordonho Carneiro, Nilufar Arashovna Elova, Gullola Amirovna Bekmurodova, Dildora Amindjanovna Amirsaidova, Astghik Pepoyan, Shakhlo Mirjamalovna Miralimova, Oleg V. Mitrokhin, Liubov S. Sichel, John Tagg, Svetoslav Dimitrov Todorov   +12 more
wiley   +1 more source